Translational models for vascular cognitive impairment: a review including larger species.

Autor:	Hainsworth AH; Clinical Neurosciences (J-0B) Molecular and Clinical Sciences Research Institute, St George's University of London, Cranmer Terrace, London, SW17 0RE, UK. ahainsworth@sgul.ac.uk.; Department of Neurology, St George's University Hospitals NHS Foundation Trust, London, UK. ahainsworth@sgul.ac.uk., Allan SM; Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PT, UK., Boltze J; Department of Translational Medicine and Cell Technology, University of Lübeck, Lübeck, Germany.; Neurovascular Research Laboratory, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA., Cunningham C; Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PT, UK., Farris C; Department of Anatomy & Neurobiology, Boston University School of Medicine, Boston, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA., Head E; Department of Pharmacology & Nutritional Sciences, Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA., Ihara M; Department of Stroke and Cerebrovascular Diseases, National Cerebral and Cardiovascular Center, Osaka, Japan., Isaacs JD; Clinical Neurosciences (J-0B) Molecular and Clinical Sciences Research Institute, St George's University of London, Cranmer Terrace, London, SW17 0RE, UK.; Department of Neurology, St George's University Hospitals NHS Foundation Trust, London, UK., Kalaria RN; Institute of Neuroscience, University of Newcastle-upon-Tyne, Newcastle-upon-Tyne, UK., Lesnik Oberstein SA; Department of Clinical Genetics, Leiden University Medical Center, Leiden, Netherlands., Moss MB; Department of Anatomy & Neurobiology, Boston University School of Medicine, Boston, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA., Nitzsche B; Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany.; Clinic for Nuclear Medicine, University of Leipzig, Leipzig, Germany.; Institute for Anatomy, Faculty of Veterinary Medicine, University of Leipzig, Leipzig, Germany., Rosenberg GA; Department of Neurology, Health Sciences Center, University of New Mexico, Albuquerque, NM, USA., Rutten JW; Department of Clinical Genetics, Leiden University Medical Center, Leiden, Netherlands.; Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands., Salkovic-Petrisic M; Department of Pharmacology, Croatian Institute for Brain Research, University of Zagreb School of Medicine, Zagreb, Croatia., Troen AM; Institute of Biochemistry Food and Nutrition Science, Hebrew University of Jerusalem, Rehovot, Israel.
Jazyk:	angličtina
Zdroj:	BMC medicine [BMC Med] 2017 Jan 25; Vol. 15 (1), pp. 16. Date of Electronic Publication: 2017 Jan 25.
DOI:	10.1186/s12916-017-0793-9
Abstrakt:	Background: Disease models are useful for prospective studies of pathology, identification of molecular and cellular mechanisms, pre-clinical testing of interventions, and validation of clinical biomarkers. Here, we review animal models relevant to vascular cognitive impairment (VCI). A synopsis of each model was initially presented by expert practitioners. Synopses were refined by the authors, and subsequently by the scientific committee of a recent conference (International Conference on Vascular Dementia 2015). Only peer-reviewed sources were cited. Methods: We included models that mimic VCI-related brain lesions (white matter hypoperfusion injury, focal ischaemia, cerebral amyloid angiopathy) or reproduce VCI risk factors (old age, hypertension, hyperhomocysteinemia, high-salt/high-fat diet) or reproduce genetic causes of VCI (CADASIL-causing Notch3 mutations). Conclusions: We concluded that (1) translational models may reflect a VCI-relevant pathological process, while not fully replicating a human disease spectrum; (2) rodent models of VCI are limited by paucity of white matter; and (3) further translational models, and improved cognitive testing instruments, are required.
Databáze:	MEDLINE
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