Necroptosis mediates the antineoplastic effects of the soluble fraction of polysaccharide from red wine in Walker-256 tumor-bearing rats.

Autor: Stipp MC; Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil., Bezerra IL; Department of Biochemistry and Molecular Biology, Federal University of Paraná, Curitiba, PR, Brazil., Corso CR; Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil., Dos Reis Livero FA; Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil., Lomba LA; Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil., Caillot AR; Department of Biochemistry and Molecular Biology, Federal University of Paraná, Curitiba, PR, Brazil., Zampronio AR; Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil., Queiroz-Telles JE; Department of Medical Pathology, Federal University of Paraná, Curitiba, PR, Brazil., Klassen G; Department of Basic Pathology, Federal University of Paraná, Curitiba, PR, Brazil., Ramos EA; Department of Basic Pathology, Federal University of Paraná, Curitiba, PR, Brazil., Sassaki GL; Department of Biochemistry and Molecular Biology, Federal University of Paraná, Curitiba, PR, Brazil., Acco A; Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil. Electronic address: aleacco@ufpr.br.
Jazyk: angličtina
Zdroj: Carbohydrate polymers [Carbohydr Polym] 2017 Mar 15; Vol. 160, pp. 123-133. Date of Electronic Publication: 2016 Dec 21.
DOI: 10.1016/j.carbpol.2016.12.047
Abstrakt: Polysaccharides are substances that modify the biological response to several stressors. The present study investigated the antitumor activity of the soluble fraction of polysaccharides (SFP), extracted from cabernet franc red wine, in Walker-256 tumor-bearing rats. The monosaccharide composition had a complex mixture, suggesting the presence of arabinoglactans, mannans, and pectins. Treatment with SFP (30 and 60mg/kg, oral) for 14days significantly reduced the tumor weight and volume compared with controls. Treatment with 60mg/kg SFP reduced blood monocytes and neutrophils, reduced the tumor activity of N-acetylglucosaminidase, myeloperoxidase, and nitric oxide, increased blood lymphocytes, and increased the levels of tumor necrosis factor α (TNF-α) in tumor tissue. Treatment with SFP also induced the expression of the cell necroptosis-related genes Rip1 and Rip3. The antineoplastic effect of SFP appears to be attributable to its action on the immune system by controlling the tumor microenvironment and stimulating TNF-α production, which may trigger the necroptosis pathway.
(Copyright © 2016 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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