Amplified Photodegradation of Cell-Laden Hydrogels via an Addition-Fragmentation Chain Transfer Reaction.

Autor: Brown TE; Department of Chemical and Biological Engineering and the BioFrontiers Institute, University of Colorado Boulder, Jennie Smoly Caruthers Biotechnology Building, 3415 Colorado Ave, Boulder, CO, 80303, USA., Marozas IA; Department of Chemical and Biological Engineering and the BioFrontiers Institute, University of Colorado Boulder, Jennie Smoly Caruthers Biotechnology Building, 3415 Colorado Ave, Boulder, CO, 80303, USA., Anseth KS; Department of Chemical and Biological Engineering and the BioFrontiers Institute, University of Colorado Boulder, Jennie Smoly Caruthers Biotechnology Building, 3415 Colorado Ave, Boulder, CO, 80303, USA.; Howard Hughes Medical Institute, University of Colorado Boulder, Jennie Smoly Caruthers Biotechnology Building, 3415 Colorado Ave, Boulder, CO, 80303, USA.
Jazyk: angličtina
Zdroj: Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2017 Mar; Vol. 29 (11). Date of Electronic Publication: 2017 Jan 23.
DOI: 10.1002/adma.201605001
Abstrakt: Hydrogels crosslinked by allyl-sulfide-containing molecules are presented. By exposure to light in the presence of a photoinitiator and a free monofunctional thiol, photodegradation is achieved. Both the gelation and degradation are cytocompatible and allow for cell encapsulation and subsequent release. The photodegradation kinetics and depths attainable are superior to those of traditional cell-laden photodegradable hydrogels.
(© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
Databáze: MEDLINE
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