Use of Cardiac Injury Markers in the Postmortem Diagnosis of Sudden Cardiac Death.

Autor: Carvajal-Zarrabal O; Biochemical and Nutrition Chemistry Area, University of Veracruz, SS Juan Pablo II s/n, 94294, Boca del Río, Veracruz, Mexico., Hayward-Jones PM; Biochemical and Nutrition Chemistry Area, University of Veracruz, SS Juan Pablo II s/n, 94294, Boca del Río, Veracruz, Mexico., Nolasco-Hipolito C; Department of Chemical Engineering and Energy Sustainability of the Faculty of Engineering, University Malaysia Sarawak (UNIMAS), Kota Samarahan, Sarawak, Malaysia., Barradas-Dermitz DM; Biological-Chemistry Area, Veracruz Institute of Technology, Calzada M.A. de Quevedo 2779, 91860, Veracruz, Ver, Mexico., Calderón-Garcidueñas AL; Institute of Forensic Medicine, University of Veracruz, SS Juan Pablo II s/n, 94294, Boca del Río, Veracruz, Mexico., López-Amador N; Institute of Forensic Medicine, University of Veracruz, SS Juan Pablo II s/n, 94294, Boca del Río, Veracruz, Mexico.
Jazyk: angličtina
Zdroj: Journal of forensic sciences [J Forensic Sci] 2017 Sep; Vol. 62 (5), pp. 1332-1335. Date of Electronic Publication: 2017 Jan 23.
DOI: 10.1111/1556-4029.13397
Abstrakt: In the daily practice of forensic pathology, sudden cardiac death (SCD) is a diagnostic challenge. Our aim was to determine the usefulness of blood biomarkers [creatine kinase CK-MB, myoglobin, troponins I and T (cTn-I and T), and lactate dehydrogenase] measured by immunoassay technique, in the postmortem diagnosis of SCD. Two groups were compared, 20 corpses with SCD and 8 controls. Statistical significance was determined by variance analysis procedures, with a post hoc Tukey multiple range test for comparison of means (p < 0.05). SCD cases showed significantly higher levels (p < 0.05) of cTn-T and cTn-I compared to the control group. Although only cases within the first 8 h of postmortem interval were included, and the control group consisted mainly of violent death cases, our results suggest that blood troponin levels may be useful to support a diagnosis of SCD.
(© 2017 American Academy of Forensic Sciences.)
Databáze: MEDLINE
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