Three Is a Crowd - New Insights into Rosetting in Plasmodium falciparum.

Autor: Yam XY; School of Biological Sciences, Nanyang Technological University, 637551, Singapore., Niang M; Immunology Unit-Pasteur Institute of Dakar, 220 Dakar, Senegal., Madnani KG; School of Biological Sciences, Nanyang Technological University, 637551, Singapore., Preiser PR; School of Biological Sciences, Nanyang Technological University, 637551, Singapore. Electronic address: prpreiser@ntu.edu.sg.
Jazyk: angličtina
Zdroj: Trends in parasitology [Trends Parasitol] 2017 Apr; Vol. 33 (4), pp. 309-320. Date of Electronic Publication: 2017 Jan 18.
DOI: 10.1016/j.pt.2016.12.012
Abstrakt: The intracellular malaria parasites extensively modify host erythrocytes to allow nutrient uptake, ensure homeostasis, and evade the host's immune response. To achieve this, the parasite exports several proteins to the erythrocyte surface. In Plasmodium falciparum, the parasite responsible for the most severe form of human malaria, three major variant surface antigen families - PfEMP1, STEVOR, and RIFIN - have been implicated in contributing to immune evasion, parasite sequestration, and parasite-mediated rosetting of uninfected erythrocytes. Sequestration and rosetting have been linked to parasite-mediated pathology, making the variant surface antigens of P. falciparum major virulence factors. Here we review our current understanding of rosetting mechanism, recent findings of STEVOR, RIFIN-mediated rosetting, and their implication on the severity and pathology of the disease.
(Copyright © 2017 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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