Age of onset of hypertension and risk of dementia in the oldest-old: The 90+ Study.

Autor:	Corrada MM; Department of Neurology, University of California Irvine, Irvine, CA, USA; Department of Epidemiology, University of California Irvine, Irvine, CA, USA; Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, CA, USA. Electronic address: mcorrada@uci.edu., Hayden KM; Department of Social Sciences and Health Policy, Wake Forest School of Medicine, Winston-Salem, NC, USA., Paganini-Hill A; Department of Neurology, University of California Irvine, Irvine, CA, USA., Bullain SS; Department of Neurology, University of California Irvine, Irvine, CA, USA; Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, CA, USA., DeMoss J; Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, CA, USA., Aguirre C; Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, CA, USA., Brookmeyer R; Department of Biostatistics, University of California, Los Angeles, Los Angeles, CA, USA., Kawas CH; Department of Neurology, University of California Irvine, Irvine, CA, USA; Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, CA, USA; Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA, USA.
Jazyk:	angličtina
Zdroj:	Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2017 Feb; Vol. 13 (2), pp. 103-110. Date of Electronic Publication: 2017 Jan 17.
DOI:	10.1016/j.jalz.2016.09.007
Abstrakt:	Introduction: We investigated the association between age of onset of hypertension and dementia risk in an oldest-old cohort. Methods: Participants are from The 90+ Study, a population-based longitudinal study of people aged 90+ who are survivors from the Leisure World Cohort Study. We estimated hypertension onset age using self-reported information from The 90+ Study and Leisure World Cohort Study, collected about 20 years earlier. A total of 559 participants without dementia were followed every 6 months for up to 10 years. Results: A total of 224 participants developed dementia during follow-up (mean = 2.8 years). Compared with those without hypertension, participants whose hypertension onset age was 80 to 89 years had a lower dementia risk (hazard ratio = 0.58, P = .04) and participants with an onset age of 90+ years had the lowest risk (hazard ratio = 0.37, P = .004). Discussion: Developing hypertension at older ages may protect against dementia. Understanding the mechanisms for this lower risk is important for determining ways to prevent dementia in the very elderly. (Copyright © 2016 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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