SIRT1-dependent anti-senescence effects of cell-deposited matrix on human umbilical cord mesenchymal stem cells.
Autor: | Zhou L; Orthopaedic Institute, Medical College, Soochow University, Suzhou, China.; Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou, China., Chen X; Orthopaedic Institute, Medical College, Soochow University, Suzhou, China.; School of Biology and Basic Medical Sciences, Medical College, Soochow University, Suzhou, China., Liu T; Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou, China., Zhu C; Orthopaedic Institute, Medical College, Soochow University, Suzhou, China., Si M; Orthopaedic Institute, Medical College, Soochow University, Suzhou, China.; Departments of Biology and Chemistry, Faculty of Science, University of Waterloo, Waterloo, ON, Canada., Jargstorf J; Orthopaedic Institute, Medical College, Soochow University, Suzhou, China.; Department of Biology, Faculty of Science, University of Waterloo, Waterloo, ON, Canada., Li M; Orthopaedic Institute, Medical College, Soochow University, Suzhou, China.; Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou, China., Pan G; Orthopaedic Institute, Medical College, Soochow University, Suzhou, China., Gong Y; School of Engineering, Sun Yat-sen University, Guangzhou, China., Luo ZP; Orthopaedic Institute, Medical College, Soochow University, Suzhou, China.; Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou, China., Yang H; Orthopaedic Institute, Medical College, Soochow University, Suzhou, China.; Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou, China., Pei M; Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics and Division of Exercise Physiology, West Virginia University, Morgantown, WV, USA., He F; Orthopaedic Institute, Medical College, Soochow University, Suzhou, China.; Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou, China. |
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Jazyk: | angličtina |
Zdroj: | Journal of tissue engineering and regenerative medicine [J Tissue Eng Regen Med] 2018 Feb; Vol. 12 (2), pp. e1008-e1021. Date of Electronic Publication: 2017 Jun 20. |
DOI: | 10.1002/term.2422 |
Abstrakt: | Human umbilical cord-derived mesenchymal stem cells (UC-MSCs) are considered an attractive cell source for tissue regeneration. However, environmental oxidative stress can trigger premature senescence in MSCs and thus compromises their regenerative potential. Extracellular matrix (ECM) derived from MSCs has been shown to facilitate cell proliferation and multi-lineage differentiation. This investigation evaluated the effect of cell-deposited decellularized ECM (DECM) on oxidative stress-induced premature senescence in UC-MSCs. Sublethal dosages of H (Copyright © 2017 John Wiley & Sons, Ltd.) |
Databáze: | MEDLINE |
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