Guanine Can Direct Binding Specificity of Ru-dipyridophenazine (dppz) Complexes to DNA through Steric Effects.

Autor: Hall JP; Department of Chemistry, University of Reading, Whiteknights, Reading, RG6 6AD, UK.; Diamond Light Source, Harwell Science and Innovation Campus, Fermi Avenue, Didcot, OX11 0QX, UK., Gurung SP; Department of Chemistry, University of Reading, Whiteknights, Reading, RG6 6AD, UK.; Diamond Light Source, Harwell Science and Innovation Campus, Fermi Avenue, Didcot, OX11 0QX, UK., Henle J; Department of Chemistry, University of Reading, Whiteknights, Reading, RG6 6AD, UK., Poidl P; Department of Chemistry, University of Reading, Whiteknights, Reading, RG6 6AD, UK., Andersson J; Department of Chemistry and Chemical Engineering, Chalmers University of Technology, 412-96, Gothenberg, Sweden.; Department of Chemistry - BMC, Uppsala University, Box 576, 751 23, Uppsala, Sweden., Lincoln P; Department of Chemistry and Chemical Engineering, Chalmers University of Technology, 412-96, Gothenberg, Sweden., Winter G; Diamond Light Source, Harwell Science and Innovation Campus, Fermi Avenue, Didcot, OX11 0QX, UK., Sorensen T; Diamond Light Source, Harwell Science and Innovation Campus, Fermi Avenue, Didcot, OX11 0QX, UK., Cardin DJ; Department of Chemistry, University of Reading, Whiteknights, Reading, RG6 6AD, UK., Brazier JA; Department of Pharmacy, University of Reading, Whiteknights, Reading, RG6 6AD, UK., Cardin CJ; Department of Chemistry, University of Reading, Whiteknights, Reading, RG6 6AD, UK.
Jazyk: angličtina
Zdroj: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2017 Apr 11; Vol. 23 (21), pp. 4981-4985. Date of Electronic Publication: 2017 Feb 06.
DOI: 10.1002/chem.201605508
Abstrakt: X-ray crystal structures of three Λ-[Ru(L) 2 dppz] 2+ complexes (dppz=dipyridophenazine; L=1,10-phenanthroline (phen), 2,2'-bipyridine (bpy)) bound to d((5BrC)GGC/GCCG) showed the compounds intercalated at a 5'-CG-3' step. The compounds bind through canted intercalation, with the binding angle determined by the guanine NH 2 group, in contrast to symmetrical intercalation previously observed at 5'-TA-3' sites. This result suggests that canted intercalation is preferred at 5'-CG-3' sites even though the site itself is symmetrical, and we hypothesise that symmetrical intercalation in a 5'-CG-3' step could give rise to a longer luminescence lifetime than canted intercalation.
(© 2017 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.)
Databáze: MEDLINE
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