When dizziness becomes sinister: oropharyngeal carcinoma presenting as a paraneoplastic neurological disorder.
| Autor: | Yong L; Department of ENT, St John's Hospital, Livingston, UK., Asimakopoulos P; Department of ENT, St John's Hospital, Livingston, UK., Mumford C; Department of Neurology, Western General Hospital, Edinburgh, UK., Fragkandrea Nixon I; Edinburgh Cancer Research Centre, Edinburgh Cancer Centre, Edinburgh, UK. |
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| Jazyk: | angličtina |
| Zdroj: | BMJ case reports [BMJ Case Rep] 2017 Jan 19; Vol. 2017. Date of Electronic Publication: 2017 Jan 19. |
| DOI: | 10.1136/bcr-2016-216151 |
| Abstrakt: | Paraneoplastic neurological disorders are uncommon presentations of head and neck cancers. We present a case of a 68-year-old male patient who presented with dizziness, nausea and memory problems. MRI of his brain showed bilateral cerebellar leptomeningeal enhancing signal abnormality with cervical lymphadenopathy. CT imaging of his neck raised the suspicion of a tonsillar primary, which was later confirmed on biopsy. His poorly differentiated HPV positive squamous cell carcinoma was treated with chemoradiotherapy. Subsequent MRI imaging showed progressive cerebellar atrophy and his presenting symptoms persisted, but he remained disease free 6 months post-treatment for his primary malignancy. Competing Interests: Conflicts of Interest: None declared. (2017 BMJ Publishing Group Ltd.) |
| Databáze: | MEDLINE |
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