Skin-to-skin contact after birth and the natural course of neurosteroid levels in healthy term newborns.

Autor: McCallie KR; Division of Neonatology, Stanford University, Palo Alto, CA, USA., Gaikwad NW; Department of Nutrition and Environmental Toxicology, University of California Davis, Davis, CA, USA., Castillo Cuadrado ME; Division of Neonatology, Stanford University, Palo Alto, CA, USA., Aleman M; Department of Veterinary Medicine, University of California Davis, Davis, CA, USA., Madigan JE; Department of Veterinary Medicine, University of California Davis, Davis, CA, USA., Stevenson DK; Division of Neonatology, Stanford University, Palo Alto, CA, USA., Bhutani VK; Division of Neonatology, Stanford University, Palo Alto, CA, USA.
Jazyk: angličtina
Zdroj: Journal of perinatology : official journal of the California Perinatal Association [J Perinatol] 2017 May; Vol. 37 (5), pp. 591-595. Date of Electronic Publication: 2017 Jan 19.
DOI: 10.1038/jp.2016.268
Abstrakt: Objective: To determine the postnatal course of neurosteroid levels in relation to gender, mode of delivery and the extent of skin-to-skin (STS) contact during the first days of life in healthy term newborns.
Study Design: Prospective observational study of 39 neonates in which parents recorded total duration of STS in the first 2 days and nine neurosteroids (dehydroepiandrosterone-sulfate, progesterone, pregnenolone, pregnenolone-sulfate, allopregnanolone, isopregnanolone, epipregnanolone, pregnanolone and pregnanolone-sulfate) were assayed from blood samples at birth and at 1-2 days of age.
Results: All nine neurosteroid levels declined significantly during the first 2 days of life. Gender did not significantly affect the change in neurosteroid levels. The decline in neurosteroid levels was generally more pronounced in vaginal deliveries, and there was a trend toward a larger decline with more exposure to STS.
Conclusion: Ongoing studies may better characterize the role of neurosteroids and the influence of STS in more critically ill and premature neonates.
Databáze: MEDLINE
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