Superparamagnetic Nanoparticles as High Efficiency Magnetic Resonance Imaging T 2 Contrast Agent.

Autor: Sousa F; Nanomedicine Laboratory, Fondazione IRCCS Istituto Neurologico Carlo Besta , AMADEOLAB, Via G.A. Amadeo 42, 20133 Milan, Italy.; IFOM The FIRC Institute of Molecular Oncology , Via Adamello 16, 20139 Milan, Italy., Sanavio B; Nanomedicine Laboratory, Fondazione IRCCS Istituto Neurologico Carlo Besta , AMADEOLAB, Via G.A. Amadeo 42, 20133 Milan, Italy., Saccani A; Nanomedicine Laboratory, Fondazione IRCCS Istituto Neurologico Carlo Besta , AMADEOLAB, Via G.A. Amadeo 42, 20133 Milan, Italy., Tang Y; Institute of Materials, Ecole Polytechnique Fédérale de Lausanne (EPFL) , Lausanne CH-1015, Switzerland.; Department of Chemistry, Laboratory of Advanced Materials, Fudan University , Shanghai 200433, China., Zucca I; Laboratory of Experimental Imaging, Fondazione IRCCS Istituto Neurologico Carlo Besta , Via Celoria 11, 20133 Milan, Italy., Carney TM; Institute of Materials, Ecole Polytechnique Fédérale de Lausanne (EPFL) , Lausanne CH-1015, Switzerland., Mastropietro A; Laboratory of Experimental Imaging, Fondazione IRCCS Istituto Neurologico Carlo Besta , Via Celoria 11, 20133 Milan, Italy., Jacob Silva PH; Institute of Materials, Ecole Polytechnique Fédérale de Lausanne (EPFL) , Lausanne CH-1015, Switzerland., Carney RP; Institute of Materials, Ecole Polytechnique Fédérale de Lausanne (EPFL) , Lausanne CH-1015, Switzerland., Schenk K; Laboratory of X-ray Diffraction, École Polytechnique Fédérale de Lausanne (EPFL) , Lausanne, CH-1015, Switzerland., Omrani AO; Laboratory for Quantum Magnetism, École Polytechnique Fédérale de Lausanne (EPFL) , Lausanne, CH-1015, Switzerland., Huang P; Laboratory for Quantum Magnetism, École Polytechnique Fédérale de Lausanne (EPFL) , Lausanne, CH-1015, Switzerland., Yang L; Laboratory for Quantum Magnetism, École Polytechnique Fédérale de Lausanne (EPFL) , Lausanne, CH-1015, Switzerland., Rønnow HM; Laboratory for Quantum Magnetism, École Polytechnique Fédérale de Lausanne (EPFL) , Lausanne, CH-1015, Switzerland., Stellacci F; Institute of Materials, Ecole Polytechnique Fédérale de Lausanne (EPFL) , Lausanne CH-1015, Switzerland., Krol S; Nanomedicine Laboratory, Fondazione IRCCS Istituto Neurologico Carlo Besta , AMADEOLAB, Via G.A. Amadeo 42, 20133 Milan, Italy.
Jazyk: angličtina
Zdroj: Bioconjugate chemistry [Bioconjug Chem] 2017 Jan 18; Vol. 28 (1), pp. 161-170. Date of Electronic Publication: 2016 Nov 28.
DOI: 10.1021/acs.bioconjchem.6b00577
Abstrakt: Nanoparticle-based magnetic resonance imaging T 2 negative agents are of great interest, and much effort is devoted to increasing cell-loading capability while maintaining low cytotoxicity. Herein, two classes of mixed-ligand protected magnetic-responsive, bimetallic gold/iron nanoparticles (Au/Fe NPs) synthesized by a two-step method are presented. Their structure, surface composition, and magnetic properties are characterized. The two classes of sulfonated Au/Fe NPs, with an average diameter of 4 nm, have an average atomic ratio of Au to Fe equal to 7 or 8, which enables the Au/Fe NPs to be superparamagnetic with a blocking temperature of 56 K and 96 K. Furthermore, preliminary cellular studies reveal that both Au/Fe NPs show very limited toxicity. MRI phantom experiments show that r 2 /r 1 ratio of Au/Fe NPs is as high as 670, leading to a 66% reduction in T 2 relaxation time. These nanoparticles provide great versatility and potential for nanoparticle-based diagnostics and therapeutic applications and as imaging contrast agents.
Databáze: MEDLINE
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