| Autor: |
Zayed RA; Clinical and Chemical Pathology Department, Faculty of Medicine, Cairo University, Cairo, Egypt., Omran D; Department of Endemic Medicine and Hepato-gastroentrology, Faculty of Medicine, Cairo University, Cairo, Egypt., Mokhtar DA; Clinical and Chemical Pathology Department, Faculty of Medicine, Cairo University, Cairo, Egypt., Zakaria Z; Department of Endemic Medicine and Hepato-gastroentrology, Faculty of Medicine, Cairo University, Cairo, Egypt., Ezzat S; Community Medicine Department, National Liver Institute, Menofia University, Menofia, Egypt., Soliman MA; Specialized Liver Unit, Kasr Alainy Hospital, Cairo University, Cairo, Egypt., Mobarak L; National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt., El-Sweesy H; Tropical Medicine Department, Cairo Fatemic Hospital, Ministry of Health, Cairo, Egypt., Emam G; Clinical Pathology Department, National Institute of Neuromotor System, Cairo, Egypt. |
| Abstrakt: |
Toll-like receptors (TLRs) are recognized as fundamental contributors to the immune system function against infections. Hepatitis C virus (HCV) infection represents a global health problem especially in Egypt having the highest HCV prevalence worldwide where HCV infection is a continuing epidemic. The aim of the present study was to investigate the possible association between genetic variation in TLR-3 and TLR-9 and HCV infection and hepatic fibrosis in chronic HCV-positive Egyptian patients. The present study included 100 naïve chronic HCV-positive patients and 100 age- and sex-matched healthy controls. Genotyping of TLR-3 (_7 C/A [rs3775296]), TLR-3 (c.1377C/T [rs3775290]) and TLR-9 (1237T/C [rs5743836]) were done by polymerase chain reaction restriction fragment length polymorphism technique. Frequency of polymorphic genotypes in TLR-3 (_7 C/A), TLR-3 (c.1377C/T) and TLR-9 (1237T/C) were not significantly different between studied HCV-positive patients and controls with P values 0.121, 0.112, and 0.683, respectively. TLR-3 c.1377 T-allele was associated with advanced stage of hepatic fibrosis ( P = 0.003). |
