Soluble Toll-like receptor 2 is a biomarker for sepsis in critically ill patients with multi-organ failure within 12 h of ICU admission.

Autor: Holst B; Department of Anaesthesia, Intensive Care and Pain Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK., Szakmany T; Department of Anaesthesia, Intensive Care and Pain Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK. szakmanyt1@cardiff.ac.uk.; ACT Directorate, Cwm Taf University Health Board, Llantrisant, CF72 8XR, UK. szakmanyt1@cardiff.ac.uk.; Anaesthetic Directorate, Aneurin Bevan University Health Board, Newport, NP20 5UB, UK. szakmanyt1@cardiff.ac.uk., Raby AC; Division of Infection and Immunity, Cardiff University, School of Medicine, Heath Park, Cardiff, CF14 4XN, UK., Hamlyn V; Department of Anaesthesia, Intensive Care and Pain Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK.; Anaesthetic Directorate, Aneurin Bevan University Health Board, Newport, NP20 5UB, UK., Durno K; Department of Anaesthesia, Intensive Care and Pain Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK., Hall JE; Department of Anaesthesia, Intensive Care and Pain Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK., Labéta MO; Division of Infection and Immunity, Cardiff University, School of Medicine, Heath Park, Cardiff, CF14 4XN, UK. Labeta@cardiff.ac.uk.
Jazyk: angličtina
Zdroj: Intensive care medicine experimental [Intensive Care Med Exp] 2017 Dec; Vol. 5 (1), pp. 2. Date of Electronic Publication: 2017 Jan 13.
DOI: 10.1186/s40635-016-0116-z
Abstrakt: Soluble TLR2 levels are elevated in infective and inflammatory conditions, but its diagnostic value with sepsis-induced multi-organ failure has not been evaluated. 37 patients with a diagnosis of severe sepsis/septic shock (sepsis) and 27 patients with organ failure without infection (SIRS) were studied. Median (IQR) plasma sTLR2 levels were 2.7 ng/ml (1.4-6.1) in sepsis and 0.6 ng/ml (0.4-0.9) in SIRS p < 0.001. sTLR2 showed good diagnostic value for sepsis at cut-off of 1.0 ng/ml, AUC:0.959. We report the ability of sTLR2 levels to discriminate between sepsis and SIRS within 12 h of ICU admission in patients with multi-organ failure.
Databáze: MEDLINE
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