Changes in the Level of Circulating hsa-miR-297 and hsa-miR-19b-3p miRNA Are Associated with Generalization of Prostate Cancer.

Autor: Osip'yants AI; BioClinicum Research and Development Centre, Moscow, Russia.; P.A. Herzen Moscow Oncology Research Institute, Ministry of Health of the Russian Federation, Moscow, Russia., Knyazev EN; BioClinicum Research and Development Centre, Moscow, Russia.; P.A. Herzen Moscow Oncology Research Institute, Ministry of Health of the Russian Federation, Moscow, Russia., Galatenko AV; BioClinicum Research and Development Centre, Moscow, Russia., Nyushko KM; P.A. Herzen Moscow Oncology Research Institute, Ministry of Health of the Russian Federation, Moscow, Russia., Galatenko VV; BioClinicum Research and Development Centre, Moscow, Russia., Shkurnikov MY; P.A. Herzen Moscow Oncology Research Institute, Ministry of Health of the Russian Federation, Moscow, Russia. mshkurnikov@gmail.com., Alekseev BY; P.A. Herzen Moscow Oncology Research Institute, Ministry of Health of the Russian Federation, Moscow, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2017 Jan; Vol. 162 (3), pp. 379-382. Date of Electronic Publication: 2017 Jan 14.
DOI: 10.1007/s10517-017-3620-6
Abstrakt: We performed diagnostic classification of plasma specimens from patients with non-metastatic and metastatic prostate cancer based on pairs of miRNA that have no individual diagnostic significance. Of 230 miRNA detected in plasma specimens, 3 pairs were diagnostically significant. The miRNA pair hsa-miR-19b-3p and hsa-miR-297 demonstrated highest sensitivity and specificity. Among common target genes of these miRNA, CFL2 gene associated with cell mobility was detected.
Databáze: MEDLINE
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