[Radiofrequency ablation in combined treatment of metastatic colorectal liver cancer].

Autor:	Skipenko OG; Department of Liver, Biliary and Pancreatic Surgery, Petrovsky Russian Research Center of Surgery, Moscow., Petrenko KN; Department of Liver, Biliary and Pancreatic Surgery, Petrovsky Russian Research Center of Surgery, Moscow., Bagmet NN; Department of Liver, Biliary and Pancreatic Surgery, Petrovsky Russian Research Center of Surgery, Moscow., Bedzhanyan AL; Department of Liver, Biliary and Pancreatic Surgery, Petrovsky Russian Research Center of Surgery, Moscow., Polishchuk LO; Department of Liver, Biliary and Pancreatic Surgery, Petrovsky Russian Research Center of Surgery, Moscow., Chardarov NK; Department of Liver, Biliary and Pancreatic Surgery, Petrovsky Russian Research Center of Surgery, Moscow., Shatveryan GA; Department of Liver, Biliary and Pancreatic Surgery, Petrovsky Russian Research Center of Surgery, Moscow.
Jazyk:	ruština
Zdroj:	Khirurgiia [Khirurgiia (Mosk)] 2016 (12), pp. 4-18.
DOI:	10.17116/hirurgia2016124-18
Abstrakt:	Aim: To study surgical and oncological outcomes in patients with metastatic colorectal liver cancer who underwent radiofrequency ablation in the structure of combined approach. Material and Methods: It is a prospective analysis of treatment of 76 patients with metastatic colorectal liver cancer who underwent RFA for the period 2004-2013. Overall survival was analyzed using univariate and multivariate analysis. Results: According to univariate analysis overall 5-year survival is negatively determined by following factors: primary localization of the tumor in rectum (36.2% and 7.2%; p=0.021); bilobed metastatic liver disease (35.9% and 15.4%; p=0.068); metastases dimensions over 5 cm (27.4% and 0%, p=0.091); augmentation of CAE levels over 4 norms (26.7% and 11.4%, p=0.09); RFA as a component of two-stage liver surgery (23.3% and 26.0%, p=0.09). Conclusion: RFA is an effective method of local antineoplastic effect for metastatic colorectal cancer. Dimensions of coagulated metastases, volume of metastatic lesion, carcinoembryonic antigen level, ablation as a component of two-stage surgery affect long-term survival after RFA.
Databáze:	MEDLINE
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