Prevalence of hormonal and endocrine dysfunction in patients with lichen planopilaris (LPP): A retrospective data analysis of 168 patients.

Autor: Ranasinghe GC; Department of Dermatology, Cleveland Clinic Foundation, Cleveland, Ohio; George Washington University School of Medicine and Health Sciences, Washington, District of Columbia., Piliang MP; Department of Dermatology, Cleveland Clinic Foundation, Cleveland, Ohio., Bergfeld WF; Department of Dermatology, Cleveland Clinic Foundation, Cleveland, Ohio. Electronic address: bergfew@ccf.org.
Jazyk: angličtina
Zdroj: Journal of the American Academy of Dermatology [J Am Acad Dermatol] 2017 Feb; Vol. 76 (2), pp. 314-320.
DOI: 10.1016/j.jaad.2016.05.038
Abstrakt: Background: Studies on the pathophysiology and comorbidities associated with lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA) are limited.
Objective: The purpose of this study was to determine the prevalence of androgen excess in the postmenopausal LPP population, in relation to demographics and comorbidities.
Methods: A retrospective data analysis of 413 patients with LPP, FFA, and LPP/FFA seen in the Department of Dermatology at the Cleveland Clinic Foundation in Ohio between 2005 and 2015 was conducted. Of this cohort, 168 patients met the inclusion criteria.
Results: Androgen excess was identified in 31.5% (n = 53) of the 168 patients with LPP and all subtypes (P < .001). Androgen deficiency was identified in 32.1% (n = 17) of the 53 patients with FFA (P < .001). The androgen excess group was significantly more likely to present with hirsutism, seborrheic dermatitis, polycystic ovary syndrome, ovarian cysts, or a combination of these (P < .001).
Limitations: This study was limited by being retrospective.
Conclusion: Our study demonstrated that LPP is associated with androgen excess, and FFA is associated with androgen deficiency.
(Copyright © 2016 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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