An Increasing Threat in an Iranian Referral Children's Hospital: Multidrug-Resistant Acinetobacter baumannii.

Autor:	Pourakbari B; Pediatric Infectious Disease Research Center, Tehran University of Medical Science, Tehran, Iran., Mahmoudi S; Pediatric Infectious Disease Research Center, Tehran University of Medical Science, Tehran, Iran., Habibi R; Department of Infectious Diseases, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran., Ashtiani MTH; Department of Pathology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran., Sadeghi RH; Pediatric Infectious Disease Research Center, Tehran University of Medical Science, Tehran, Iran., Khodabandeh M; Department of Infectious Diseases, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran., Mamishi S; Pediatric Infectious Disease Research Center, Tehran University of Medical Science, Tehran, Iran.; Department of Infectious Diseases, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
Jazyk:	angličtina
Zdroj:	Infectious disorders drug targets [Infect Disord Drug Targets] 2018; Vol. 18 (2), pp. 129-135.
DOI:	10.2174/1871526517666170113144541
Abstrakt:	Introduction: Acinetobacter baumannii has emerged as an important nosocomial pathogen in the past decades. Due to the prevalence of A. baumannii across the world, suitable typing methods to investigate the epidemiological distribution of the organism have been developed. The aim of this study was to investigate the epidemiological and molecular diversity of A. baumannii strains isolated from nosocomial infections of hospitalized children in Children Medical Center Hospital (CMC), an Iranian referral hospital, in Tehran, Iran. Material and Methods: A total of 27 non-duplicate clinical A. baumannii isolates were collected during October 2013 to March 2014 and tested for antimicrobial resistance to several antibiotic agents. The genetic similarity of the strains was investigated by amplification of Random amplified polymorphic DNA-polymerase chain reaction (RAPD-PCR) method. Results: One predominant RAPD profile (type B) was identified in 15 strains (56% of all typed isolates). Other clusters depicted in the dendrogram, namely A, C, and D comprised 6 (22%), 5 (19%) and 1 (3%) isolates, respectively. All A. baumannii strains were resistant to all antibiotics except colistin. Conclusion: This study highlights the clonal spread of multidrug-resistant A. baumannii in our hospital. Therefore, the factors responsible for dissemination of such isolates need to be identified, controlled, and prevented to avoid major outbreaks. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.)
Databáze:	MEDLINE
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