Manipulation of tumor oxygenation and radiosensitivity through modification of cell respiration. A critical review of approaches and imaging biomarkers for therapeutic guidance.

Autor: Gallez B; Louvain Drug Research Institute, Biomedical Magnetic Resonance Research Group, Université catholique de Louvain, Avenue Mounier 73.08, B-1200 Brussels, Belgium. Electronic address: bernard.gallez@uclouvain.be., Neveu MA; Louvain Drug Research Institute, Biomedical Magnetic Resonance Research Group, Université catholique de Louvain, Avenue Mounier 73.08, B-1200 Brussels, Belgium., Danhier P; Louvain Drug Research Institute, Biomedical Magnetic Resonance Research Group, Université catholique de Louvain, Avenue Mounier 73.08, B-1200 Brussels, Belgium., Jordan BF; Louvain Drug Research Institute, Biomedical Magnetic Resonance Research Group, Université catholique de Louvain, Avenue Mounier 73.08, B-1200 Brussels, Belgium.
Jazyk: angličtina
Zdroj: Biochimica et biophysica acta. Bioenergetics [Biochim Biophys Acta Bioenerg] 2017 Aug; Vol. 1858 (8), pp. 700-711. Date of Electronic Publication: 2017 Jan 12.
DOI: 10.1016/j.bbabio.2017.01.002
Abstrakt: Tumor hypoxia has long been considered as a detrimental factor for the response to irradiation. In order to improve the sensitivity of tumors cells to radiation therapy, tumor hypoxia may theoretically be alleviated by increasing the oxygen delivery or by decreasing the oxygen consumption by tumor cells. Mathematical modelling suggested that decreasing the oxygen consumption should be more efficient than increasing oxygen delivery in order to alleviate tumor hypoxia. In this paper, we review several promising strategies targeting the mitochondrial respiration for which alleviation of tumor hypoxia and increase in sensitivity to irradiation have been demonstrated. Because the translation of these approaches into the clinical arena requires the use of pharmacodynamics biomarkers able to identify shift in oxygen consumption and tumor oxygenation, we also discuss the relative merits of imaging biomarkers (Positron Emission Tomography and Magnetic Resonance) that may be used for therapeutic guidance. This article is part of a Special Issue entitled Mitochondria in Cancer, edited by Giuseppe Gasparre, Rodrigue Rossignol and Pierre Sonveaux.
(Copyright © 2017 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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