The route from problem to solution in multistep continuous flow synthesis of pharmaceutical compounds.

Autor: Bana P; Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, H-1521 Budapest, Hungary., Örkényi R; Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, H-1521 Budapest, Hungary., Lövei K; Gedeon Richter Plc., Gyömrői út 19-21, H-1103 Budapest, Hungary., Lakó Á; Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, H-1521 Budapest, Hungary., Túrós GI; Gedeon Richter Plc., Gyömrői út 19-21, H-1103 Budapest, Hungary., Éles J; Gedeon Richter Plc., Gyömrői út 19-21, H-1103 Budapest, Hungary., Faigl F; Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, H-1521 Budapest, Hungary; MTA-BME Organic Chemical Technology Research Group, Budafoki út 8, H-1111 Budapest, Hungary., Greiner I; Gedeon Richter Plc., Gyömrői út 19-21, H-1103 Budapest, Hungary. Electronic address: i.greiner@richter.hu.
Jazyk: angličtina
Zdroj: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2017 Dec 01; Vol. 25 (23), pp. 6180-6189. Date of Electronic Publication: 2016 Dec 29.
DOI: 10.1016/j.bmc.2016.12.046
Abstrakt: Recent advances in the field of continuous flow chemistry allow the multistep preparation of complex molecules such as APIs (Active Pharmaceutical Ingredients) in a telescoped manner. Numerous examples of laboratory-scale applications are described, which are pointing towards novel manufacturing processes of pharmaceutical compounds, in accordance with recent regulatory, economical and quality guidances. The chemical and technical knowledge gained during these studies is considerable; nevertheless, connecting several individual chemical transformations and the attached analytics and purification holds hidden traps. In this review, we summarize innovative solutions for these challenges, in order to benefit chemists aiming to exploit flow chemistry systems for the synthesis of biologically active molecules.
(Copyright © 2016 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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