Effects of Diet and Metformin on placental morphology in Gestational Diabetes Mellitus.

Autor:	Arshad R; Dr. Rabia Arshad, MBBS, M. Phil. Assistant Professor and Head of Pharmacology Department, Altamash Institute of Dental Medicine, 2-R Sunset Boulevard, DHA, Karachi, Pakistan., Kanpurwala MA; Dr. Muhammad Adnan Kanpurwala, MBBS, M. Phil. Associate Professor, Physiology Department, Karachi Institute of Medical Sciences, Karachi, Pakistan., Karim N; Dr. Nasim Karim, MBBS, M. Phil, Ph D, Post Doc. Professor and Head of Pharmacology Department, Bahria University Medical and Dental College, Karachi, Pakistan., Hassan JA; Dr. Jahan Ara Hasan, MBBS, FCPS, MCPS. Associate Professor, Gynecology and Obstetrics Department, Dow University of Health Sciences, Karachi, Pakistan.
Jazyk:	angličtina
Zdroj:	Pakistan journal of medical sciences [Pak J Med Sci] 2016 Nov-Dec; Vol. 32 (6), pp. 1522-1527.
DOI:	10.12669/pjms.326.10872
Abstrakt:	Objective: To evaluate the effects of diet control and Metformin on placental morphology in gestational diabetes mellitus (GDM). Methods: After written informed consent 62 GDMs were enrolled. According to WHO criteria, 30 cases of GDMs with blood sugar level <130 mg/dl, were assigned Group B (2000-2500Kcal/day and 30 minute walk thrice weekly were kept on diet control and 32 cases of GDM with blood sugar level >130 mg/dl, assigned Group C were kept on diet with tablet Metformin,(500mg TDS) Finally 25 normal pregnant females were kept in Group A as control. After delivery placentae were preserved and evaluated for morphology. Results: Heavy placentae with abundant villous immaturity, chorangiosis and syncytial knots in group B and fibrinoid necrosis and calcification in group C were seen. In group B versus A placental and cord width while in Group C versus A only cord width in gross morphology showed significant results. In group B versus A villous immaturity, chorangiosis, infarction and syncytial knots in light microscopy were present; similarly in B versus C placental width, chorangiosis and syncytial knots showed significant results, while in C versus A results were non-significant. Conclusion: Metformin produced beneficial effects on placental morphology being comparable to normal control in contrast to diet group.
Databáze:	MEDLINE
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