Differential expression of cord blood neurotrophins in gestational diabetes: the impact of fetal growth abnormalities.

Autor:	Briana DD; a Department of Neonatology , National and Kapodistrian University of Athens , Athens , Greece., Papastavrou M; a Department of Neonatology , National and Kapodistrian University of Athens , Athens , Greece., Boutsikou M; a Department of Neonatology , National and Kapodistrian University of Athens , Athens , Greece., Marmarinos A; b Laboratory of Clinical Biochemistry-Molecular Diagnostics, 2nd Department of Pediatrics , National and Kapodistrian University of Athens , Athens , Greece., Gourgiotis D; b Laboratory of Clinical Biochemistry-Molecular Diagnostics, 2nd Department of Pediatrics , National and Kapodistrian University of Athens , Athens , Greece., Malamitsi-Puchner A; a Department of Neonatology , National and Kapodistrian University of Athens , Athens , Greece.
Jazyk:	angličtina
Zdroj:	The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians [J Matern Fetal Neonatal Med] 2018 Feb; Vol. 31 (3), pp. 278-283. Date of Electronic Publication: 2017 Feb 02.
DOI:	10.1080/14767058.2017.1281907
Abstrakt:	Objective: Gestational diabetes mellitus (GDM) may induce fetal macrosomia or growth restriction and is associated with later offspring neurodevelopmental disorders. We aimed to determine whether neurotrophins brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF) and neurotrophin-4 (NT-4) are differentially expressed in cord blood samples at birth in large-for-gestational-age (LGA), intrauterine-growth-restricted (IUGR) and appropriate-for-gestational-age (AGA) offspring of diabetic mothers, as compared to AGA controls from non-diabetic mothers. Methods: BDNF, NGF and NT-4 concentrations were prospectively determined in 80 cord blood samples from LGA (n = 15), IUGR (n = 12) and AGA (n = 33) diabetic, as well as from AGA normal (controls, n = 20) singleton full-term pregnancies. Results: Fetal BDNF concentrations considerably decreased in GDM, as compared with normal pregnancies [(b = -2.836, 95%CI -5.067 to (-0.604), p = 0.013)] and were higher in females (b = 2.298, 95%CI 0.357-4.238, p = 0.021). Cord blood NGF concentrations were lower in IUGR than AGA infants (p = 0.038). Conclusions: BDNF is down-regulated in the fetus exposed to GDM, independently of the fetal growth pattern, probably representing a candidate mechanism underlying the association between maternal diabetes and later psychopathology. IUGR fetuses born to diabetic mothers present with NGF deficiency, which may contribute to their long-term neurodevelopmental sequelae. Gender-dependent differences in fetal BDNF may partly explain the higher prevalence of adverse neurodevelopmental outcomes following brain insults in male infants.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu