Does brain creatine content rely on exogenous creatine in healthy youth? A proof-of-principle study.

Autor: Merege-Filho CA; a Applied Physiology and Nutrition Research Group, School of Physical Education and Sports, University of Sao Paulo, Sao Paulo, SP 05508-030, Brazil.; b Rheumatology Division, School of Medicine, University of Sao Paulo, Sao Paulo 01246903, Brazil., Otaduy MC; c Institute of Radiology and Oncology, School of Medicine, University of Sao Paulo, Sao Paulo 01246903, Brazil., de Sá-Pinto AL; b Rheumatology Division, School of Medicine, University of Sao Paulo, Sao Paulo 01246903, Brazil., de Oliveira MO; d Neurology Division, School of Medicine, University of Sao Paulo, Sao Paulo 01246903, Brazil., de Souza Gonçalves L; a Applied Physiology and Nutrition Research Group, School of Physical Education and Sports, University of Sao Paulo, Sao Paulo, SP 05508-030, Brazil.; b Rheumatology Division, School of Medicine, University of Sao Paulo, Sao Paulo 01246903, Brazil., Hayashi AP; a Applied Physiology and Nutrition Research Group, School of Physical Education and Sports, University of Sao Paulo, Sao Paulo, SP 05508-030, Brazil.; b Rheumatology Division, School of Medicine, University of Sao Paulo, Sao Paulo 01246903, Brazil., Roschel H; a Applied Physiology and Nutrition Research Group, School of Physical Education and Sports, University of Sao Paulo, Sao Paulo, SP 05508-030, Brazil.; b Rheumatology Division, School of Medicine, University of Sao Paulo, Sao Paulo 01246903, Brazil., Pereira RM; b Rheumatology Division, School of Medicine, University of Sao Paulo, Sao Paulo 01246903, Brazil., Silva CA; b Rheumatology Division, School of Medicine, University of Sao Paulo, Sao Paulo 01246903, Brazil., Brucki SM; d Neurology Division, School of Medicine, University of Sao Paulo, Sao Paulo 01246903, Brazil., da Costa Leite C; c Institute of Radiology and Oncology, School of Medicine, University of Sao Paulo, Sao Paulo 01246903, Brazil., Gualano B; a Applied Physiology and Nutrition Research Group, School of Physical Education and Sports, University of Sao Paulo, Sao Paulo, SP 05508-030, Brazil.; b Rheumatology Division, School of Medicine, University of Sao Paulo, Sao Paulo 01246903, Brazil.
Jazyk: angličtina
Zdroj: Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme [Appl Physiol Nutr Metab] 2017 Feb; Vol. 42 (2), pp. 128-134. Date of Electronic Publication: 2016 Oct 05.
DOI: 10.1139/apnm-2016-0406
Abstrakt: It has been hypothesized that dietary creatine could influence cognitive performance by increasing brain creatine in developing individuals. This double-blind, randomized, placebo-controlled, proof-of-principle study aimed to investigate the effects of creatine supplementation on cognitive function and brain creatine content in healthy youth. The sample comprised 67 healthy participants aged 10 to 12 years. The participants were given creatine or placebo supplementation for 7 days. At baseline and after the intervention, participants undertook a battery of cognitive tests. In a random subsample of participants, brain creatine content was also assessed in the regions of left dorsolateral prefrontal cortex, left hippocampus, and occipital lobe by proton magnetic resonance spectroscopy (1H-MRS) technique. The scores obtained from verbal learning and executive functions tests did not significantly differ between groups at baseline or after the intervention (all p > 0.05). Creatine content was not significantly different between groups in left dorsolateral prefrontal cortex, left hippocampus, and occipital lobe (all p > 0.05). In conclusion, a 7-day creatine supplementation protocol did not elicit improvements in brain creatine content or cognitive performance in healthy youth, suggesting that this population mainly relies on brain creatine synthesis rather than exogenous creatine intake to maintain brain creatine homeostasis.
Databáze: MEDLINE
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