Muscle-Nerve-Muscle Grafting for Facial Reanimation in Rats.

Autor:	Charous SJ; 1 Loyola University of Chicago, Department of Otolaryngology-Head and Neck Surgery, Maywood, Illinois, USA., Hotaling JM; 1 Loyola University of Chicago, Department of Otolaryngology-Head and Neck Surgery, Maywood, Illinois, USA., Burgess BD; 1 Loyola University of Chicago, Department of Otolaryngology-Head and Neck Surgery, Maywood, Illinois, USA., Sappington JM; 1 Loyola University of Chicago, Department of Otolaryngology-Head and Neck Surgery, Maywood, Illinois, USA., Park J; 2 Loyola University of Chicago, Stritch School of Medicine, Maywood, Illinois, USA., Turek G; 2 Loyola University of Chicago, Stritch School of Medicine, Maywood, Illinois, USA., Foecking EM; 1 Loyola University of Chicago, Department of Otolaryngology-Head and Neck Surgery, Maywood, Illinois, USA.; 3 Edward Hines Jr. VA Hospital, Hines, Illinois, USA.
Jazyk:	angličtina
Zdroj:	The Annals of otology, rhinology, and laryngology [Ann Otol Rhinol Laryngol] 2017 Apr; Vol. 126 (4), pp. 261-267. Date of Electronic Publication: 2017 Jan 10.
DOI:	10.1177/0003489416686587
Abstrakt:	Objective: Facial paralysis is a devastating condition leaving patients with a myriad of aesthetic and functional consequences. Muscle-nerve-muscle (MNM) neurotization is a reinnervation technique that involves implanting an autogenous nerve graft as a conduit between an innervated "donor" muscle and a denervated "recipient" muscle. We investigated the use of MNM reinnervation, alone or in combination with electrical stimulation (ES) and testosterone propionate (TP) in comparison to nerve reanastomosis (RE), on functional recovery following rat facial nerve injury. Methods: Thirty-one male, Sprague-Dawley rats were assigned to groups: no graft (control), MNM grafting alone (MNM), MNM grafting with ES and TP (MNM+ES+TP), or RE. Harvested right facial nerve branches were used as the MNM graft. Functional recovery was assessed by behavioral observations and electromyographic recordings. Results: The MNM grafting improved muscle tone and vibrissae movement. The ES+TP treatment further enhanced muscle tone as well as reduced recovery time for coordinated movement in a manner that is comparable to those of RE. Electromyographic recordings demonstrated electrical conductance across all MNM grafts. Conclusion: These data have important implications for patients with unilateral paralysis from facial or laryngeal nerve injury, particularly those who are not candidates for nerve reanastomosis.
Databáze:	MEDLINE
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