Differential effects of myostatin deficiency on motor and sensory axons.

Autor: Jones MR; Department of Biological Sciences, University of Missouri, Columbia, Missouri, USA.; C.S. Bond Life Sciences Center, University of Missouri, 1201 East Rollins Road, Columbia, Missouri, 65211, USA., Villalón E; Department of Biological Sciences, University of Missouri, Columbia, Missouri, USA.; C.S. Bond Life Sciences Center, University of Missouri, 1201 East Rollins Road, Columbia, Missouri, 65211, USA., Northcutt AJ; Department of Biological Sciences, University of Missouri, Columbia, Missouri, USA., Calcutt NA; Department of Pathology, University of California San Diego, La Jolla, California, USA., Garcia ML; Department of Biological Sciences, University of Missouri, Columbia, Missouri, USA.; C.S. Bond Life Sciences Center, University of Missouri, 1201 East Rollins Road, Columbia, Missouri, 65211, USA.
Jazyk: angličtina
Zdroj: Muscle & nerve [Muscle Nerve] 2017 Dec; Vol. 56 (6), pp. E100-E107. Date of Electronic Publication: 2017 Apr 11.
DOI: 10.1002/mus.25570
Abstrakt: Introduction: Deletion of myostatin in mice (MSTN -/- ) alters structural properties of peripheral axons. However, properties like axon diameter and myelin thickness were analyzed in mixed nerves, so it is unclear whether loss of myostatin affects motor, sensory, or both types of axons.
Methods: Using the MSTN -/- mouse model, we analyzed the effects of increasing the number of muscle fibers on axon diameter, myelin thickness, and internode length in motor and sensory axons.
Results: Axon diameter and myelin thickness were increased in motor axons of MSTN -/- mice without affecting internode length or axon number. The number of sensory axons was increased without affecting their structural properties.
Discussion: These results suggest that motor and sensory axons establish structural properties by independent mechanisms. Moreover, in motor axons, instructive cues from the neuromuscular junction may play a role in co-regulating axon diameter and myelin thickness, whereas internode length is established independently. Muscle Nerve 56: E100-E107, 2017.
(© 2017 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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