Nasopharyngeal carriage of respiratory pathogens in Warao Amerindians: significant relationship with stunting.

Autor: Verhagen LM; Laboratorio de Tuberculosis, Universidad Central de Venezuela, Caracas, Venezuela.; Laboratory of Pediatric Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.; Wilhelmina Children's Hospital Utrecht, Utrecht, The Netherlands., Hermsen M; Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands., Rivera-Olivero IA; Laboratorio de Tuberculosis, Universidad Central de Venezuela, Caracas, Venezuela., Sisco MC; Laboratorio de Tuberculosis, Universidad Central de Venezuela, Caracas, Venezuela., de Jonge MI; Laboratory of Pediatric Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands., Hermans PW; Laboratory of Pediatric Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands., de Waard JH; Laboratorio de Tuberculosis, Universidad Central de Venezuela, Caracas, Venezuela.
Jazyk: angličtina
Zdroj: Tropical medicine & international health : TM & IH [Trop Med Int Health] 2017 Apr; Vol. 22 (4), pp. 407-414. Date of Electronic Publication: 2017 Feb 09.
DOI: 10.1111/tmi.12835
Abstrakt: Objective: To assess risk factors for nasopharyngeal carriage of potential pathogens in geographically isolated Warao Amerindians in Venezuela.
Methods: In this point prevalence survey, nasopharyngeal swabs were obtained from 1064 Warao Amerindians: 504 children aged 0-4 years, 227 children aged 5-10 years and 333 caregivers. Written questionnaires were completed to obtain information on demographics and environmental risk factors. Anthropometric measurements were performed in children aged 0-4 years.
Results: Carriage rates of Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae and Moraxella catarrhalis were 51%, 7%, 1% and 13%, respectively. Crowding index, method of cooking and tobacco exposure were not associated with increased carriage. In multivariable analysis, an increase in height-for-age Z score (i.e. improved chronic nutritional status) was associated with decreased odds of S. pneumoniae colonisation (OR 0.76, 95% CI 0.70-0.83) in children aged 0-4 years.
Conclusions: Better knowledge of demographic and environmental risk factors facilitates better understanding of the dynamics of colonisation with respiratory bacteria in an Amerindian population. Poor chronic nutritional status was associated with increased pathogen carriage in children <5 years of age. The high rates of stunting generally observed in indigenous children may fuel the acquisition of respiratory bacteria that can lead to respiratory and invasive disease.
(© 2017 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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