A molecular portrait of maternal sepsis from Byzantine Troy.

Autor:	Devault AM; McMaster Ancient DNA Centre, Department of Anthropology, McMaster University, Hamilton, Canada.; MYcroarray, Ann Arbor, United States., Mortimer TD; Department of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, United States.; Microbiology Doctoral Training Program, University of Wisconsin-Madison, Madison, United States., Kitchen A; Department of Anthropology, University of Iowa, Iowa City, United States., Kiesewetter H; Project Troia, Institute of Prehistory, Early History, and Medieval Archaeology, Tübingen University, Tübingen, Germany., Enk JM; McMaster Ancient DNA Centre, Department of Anthropology, McMaster University, Hamilton, Canada.; MYcroarray, Ann Arbor, United States., Golding GB; Department of Biology, McMaster University, Hamilton, Canada., Southon J; Keck Carbon Cycle Accelerator Mass Spectrometer, Earth Systems Science Department, University of California, Irvine, United States., Kuch M; McMaster Ancient DNA Centre, Department of Anthropology, McMaster University, Hamilton, Canada., Duggan AT; McMaster Ancient DNA Centre, Department of Anthropology, McMaster University, Hamilton, Canada., Aylward W; Molecular Archaeology Laboratory, Biotechnology Center, University of Wisconsin-Madison, Madison, United States.; Department of Classics and Ancient Near Eastern Studies, University of Wisconsin-Madison, Madison, United States., Gardner SN; Lawrence Livermore National Laboratory, Livermore, United States., Allen JE; Lawrence Livermore National Laboratory, Livermore, United States., King AM; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Canada., Wright G; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Canada., Kuroda M; Laboratory of Bacterial Genomics, Pathogen Genomics Center, National Institute of Infectious Diseases, Tokyo, Japan., Kato K; Laboratory of Bacterial Genomics, Pathogen Genomics Center, National Institute of Infectious Diseases, Tokyo, Japan., Briggs DE; Department of Geology and Geophysics, Yale University, New Haven, United States., Fornaciari G; Division of Paleopathology, Department of Translational Research on New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy., Holmes EC; Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Life and Environmental Sciences and Sydney Medical School, The University of Sydney, Sydney, Australia., Poinar HN; McMaster Ancient DNA Centre, Department of Anthropology, McMaster University, Hamilton, Canada.; Department of Biology, McMaster University, Hamilton, Canada.; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Canada.; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, Canada., Pepperell CS; Department of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, United States.; Molecular Archaeology Laboratory, Biotechnology Center, University of Wisconsin-Madison, Madison, United States.; Department of Medicine (Infectious Diseases), School of Medicine and Public Health, University of Wisconsin-Madison, Madison, United States.
Jazyk:	angličtina
Zdroj:	ELife [Elife] 2017 Jan 10; Vol. 6. Date of Electronic Publication: 2017 Jan 10.
DOI:	10.7554/eLife.20983
Abstrakt:	Pregnancy complications are poorly represented in the archeological record, despite their importance in contemporary and ancient societies. While excavating a Byzantine cemetery in Troy, we discovered calcified abscesses among a woman's remains. Scanning electron microscopy of the tissue revealed 'ghost cells', resulting from dystrophic calcification, which preserved ancient maternal, fetal and bacterial DNA of a severe infection, likely chorioamnionitis. Gardnerella vaginalis and Staphylococcus saprophyticus dominated the abscesses. Phylogenomic analyses of ancient, historical, and contemporary data showed that G. vaginalis Troy fell within contemporary genetic diversity, whereas S. saprophyticus Troy belongs to a lineage that does not appear to be commonly associated with human disease today. We speculate that the ecology of S. saprophyticus infection may have differed in the ancient world as a result of close contacts between humans and domesticated animals. These results highlight the complex and dynamic interactions with our microbial milieu that underlie severe maternal infections. Competing Interests: The authors declare that no competing interests exist.
Databáze:	MEDLINE
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