| Autor: |
Aulakh JK; Department of Chemistry, Guru Nanak Dev University, Amritsar - 143 005, India. tarlokslobana@yahoo.co.in., Lobana TS; Department of Chemistry, Guru Nanak Dev University, Amritsar - 143 005, India. tarlokslobana@yahoo.co.in., Sood H; Department of Microbiology, Guru Nanak Dev University, Amritsar-143 005, India., Arora DS; Department of Microbiology, Guru Nanak Dev University, Amritsar-143 005, India., Garcia-Santos I; Departamento de Quimica Inorganica, Facultad de Farmacia, Universidad de Santiago, 15782-Santiago, Spain., Hundal G; Department of Chemistry, Guru Nanak Dev University, Amritsar - 143 005, India. tarlokslobana@yahoo.co.in., Kaur M; Department of Chemistry, Keene State College, Keene, NH 03435-2001, USA., Smolenski VA; Department of Chemistry, Keene State College, Keene, NH 03435-2001, USA., Jasinski JP; Department of Chemistry, Keene State College, Keene, NH 03435-2001, USA. |
| Abstrakt: |
An equimolar reaction of copper(i) iodide with N-ethyl-imidazolidine-2-thione (l-Et) in acetonitrile formed black prismatic crystals over a period of three weeks. The X-ray structure determination of black crystals revealed that the thio-ligand l-Et has transformed into a new thio-ligand, 1-ethyl-3-(1-ethyl-4,5-dihydro-1H-imidazol-2-yl)imidazolidine-2-thione (l-NEt), through C-S rupture/C-N bond formation which was coordinated in the unusual 2D polymer, {(Cu II (κ 2 -N,S-l-NEt) 2 )·(CuI 4 )·(CuI 2 )} n 1. An ESR spectrum supported the presence of divalent Cu II in the polymer. In contrast, reaction of copper(i) iodide with N-phenyl-imidazolidine-2-thione (l-Ph) in 1 : 1 molar ratio yielded a polymer, [-Cu(μ-I) 2 Cu(μ-S-l-Ph) 2 Cu-] n 2, with alternate Cu 2 I 2 and Cu 2 S 2 cores. Further, a series of reactions of copper(i) halides with N-substituted imidazolidine-2-thiones, namely, l-R in 1 : 2 metal to ligand molar ratio (M : L) in acetonitrile have yielded different type of complexes: trigonal planar {CuX(κ 1 -S-l-R) 2 , R, X : Et, I, 4; Me, I, 5; Bu n , I,6; Me, Br,7; Bu n , Br, 8; Me, Cl, 9; Pr n , Cl, 10; Ph, Cl, 11}, dinuclear [Cu 2 Br 2 (μ-S-l-Ph) 2 (κ 1 -S-l-Ph) 2 ] 12, tetranuclear, [Cu 4 I 2 (μ-I) 2 (μ-S-l-Ph) 4 (κ 1 -S-l-Ph) 2 ] 3 and hexanuclear [Cu 6 Cl 6 (μ-S-l-Bu n ) 6 ] 13. All these complexes have been characterized using analytical data, IR and proton NMR spectroscopy, ESI-mass studies and single crystal X-ray crystallography. The antimicrobial activity of these complexes has been investigated against Gram positive bacteria, namely, Staphylococcus aureus (MTCC740), methicillin resistant Staphylococcus aureus (MRSA), Gram negative bacteria, Klebsiella pneumoniae (MTCC109), Salmonella typhimurium (MTCC741) and Candida albicans (MTCC227)- a yeast. It is significant to add that among various complexes tested for cytotoxicity toward living cells, 4, 5, 8, 9 and 10 complexes were toxic, while complex 12 was non-toxic. |
