| Autor: |
Ferro TA; Programa de Pós-graduação, Universidade CEUMA São Luís, Brazil., Araújo JM; Programa de Pós-graduação, Universidade CEUMA São Luís, Brazil., Dos Santos Pinto BL; Programa de Pós-graduação, Universidade CEUMA São Luís, Brazil., Dos Santos JS; Programa de Pós-graduação, Universidade CEUMA São Luís, Brazil., Souza EB; Programa de Pós-graduação, Universidade CEUMA São Luís, Brazil., da Silva BL; Programa de Pós-graduação, Universidade CEUMA São Luís, Brazil., Colares VL; Programa de Pós-graduação, Universidade CEUMA São Luís, Brazil., Novais TM; Programa de Pós-graduação, Universidade CEUMA São Luís, Brazil., Filho CM; Universidade Federal de Pernambuco Pernambuco, Brazil., Struve C; Statens Serum Institut Copenhagen, Denmark., Calixto JB; Centro de Inovação e Estudos Pré-clínicos Florianópolis, Brazil., Monteiro-Neto V; Programa de Pós-graduação, Universidade CEUMASão Luís, Brazil; Universidade Federal do MaranhãoSão Luís, Brazil., da Silva LC; Programa de Pós-graduação, Universidade CEUMA São Luís, Brazil., Fernandes ES; Programa de Pós-graduação, Universidade CEUMA São Luís, Brazil. |
| Abstrakt: |
Bacterial resistance to the available marketed drugs has prompted the search of novel therapies; especially in regards of anti-virulence strategies that aim to make bacteria less pathogenic and/or decrease their probability to become resistant to therapy. Cinnamaldehyde is widely known for its antibacterial properties through mechanisms that include the interaction of this compound with bacterial cell walls. However, only a handful of studies have addressed its effects on bacterial virulence, especially when tested at sub-inhibitory concentrations. Herein, we show for the first time that cinnamaldehyde is bactericidal against Staphylococcus aureus and Enterococcus faecalis multidrug resistant strains and does not promote bacterial tolerance. Cinnamaldehyde actions were stronger on S. aureus as it was able to inhibit its hemolytic activity on human erythrocytes and reduce its adherence to latex. Furthermore, cinnamaldehyde enhanced the serum-dependent lysis of S. aureus . In vivo testing of cinnamaldehyde in Galleria mellonella larvae infected with S. aureus , showed this compound improves larvae survival whilst diminishing bacterial load in their hemolymph. We suggest that cinnamaldehyde may represent an alternative therapy to control S. aureus -induced bacterial infections as it presents the ability to reduce bacterial virulence/survival without promoting an adaptive phenotype. |
