White matter lesions relate to tract-specific reductions in functional connectivity.

Autor: Langen CD; Department of Radiology and Nuclear Medicine, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Medical Informatics, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands., Zonneveld HI; Department of Radiology and Nuclear Medicine, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Epidemiology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands., White T; Department of Radiology and Nuclear Medicine, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Child and Adolescent Psychiatry, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands., Huizinga W; Department of Radiology and Nuclear Medicine, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Medical Informatics, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands., Cremers LGM; Department of Radiology and Nuclear Medicine, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Epidemiology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands., de Groot M; Department of Radiology and Nuclear Medicine, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Medical Informatics, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Epidemiology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands., Ikram MA; Department of Radiology and Nuclear Medicine, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Epidemiology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands., Niessen WJ; Department of Radiology and Nuclear Medicine, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Medical Informatics, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Imaging Physics, Faculty of Applied Sciences, Delft University of Technology, Delft, the Netherlands., Vernooij MW; Department of Radiology and Nuclear Medicine, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Epidemiology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands. Electronic address: m.vernooij@erasmusmc.nl.
Jazyk: angličtina
Zdroj: Neurobiology of aging [Neurobiol Aging] 2017 Mar; Vol. 51, pp. 97-103. Date of Electronic Publication: 2016 Dec 14.
DOI: 10.1016/j.neurobiolaging.2016.12.004
Abstrakt: White matter lesions play a role in cognitive decline and dementia. One presumed pathway is through disconnection of functional networks. Little is known about location-specific effects of lesions on functional connectivity. This study examined location-specific effects within anatomically-defined white matter tracts in 1584 participants of the Rotterdam Study, aged 50-95. Tracts were delineated from diffusion magnetic resonance images using probabilistic tractography. Lesions were segmented on fluid-attenuated inversion recovery images. Functional connectivity was defined across each tract on resting-state functional magnetic resonance images by using gray matter parcellations corresponding to the tract ends and calculating the correlation of the mean functional activity between the gray matter regions. A significant relationship between both local and brain-wide lesion load and tract-specific functional connectivity was found in several tracts using linear regressions, also after Bonferroni correction. Indirect connectivity analyses revealed that tract-specific functional connectivity is affected by lesions in several tracts simultaneously. These results suggest that local white matter lesions can decrease tract-specific functional connectivity, both in direct and indirect connections.
(Copyright © 2016 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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