Ritonavir and Topical Ocular Corticosteroid Induced Cushing's Syndrome in an Adolescent With HIV-1 Infection.
| Autor: | Rainsbury PG; From the *University Hospital Southampton, Southampton, Hampshire, United Kingdom; †NHS Foundation Trust, United Kingdom; ‡Imperial College London, Kensington, London, United Kingdom; §Portsmouth Hospitals, Portsmouth, United Kingdom; and ¶Poole Hospitals, Poole, United Kingdom., Sharp J, Tappin A, Hussey M, Lenko A, Foster C |
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| Jazyk: | angličtina |
| Zdroj: | The Pediatric infectious disease journal [Pediatr Infect Dis J] 2017 May; Vol. 36 (5), pp. 502-503. |
| DOI: | 10.1097/INF.0000000000001534 |
| Abstrakt: | Cushing's syndrome after topical ocular corticosteroid use is extremely rare. We describe a case of symptomatic Cushing's syndrome in an adolescent male with sight-threatening vernal keratoconjunctivitis on antiretroviral therapy for HIV-1 infection that included ritonavir, a potent cytochrome p450 CYP3A4 inhibitor. CYP3A4 inhibition reduces the metabolism of exogenous corticosteroids leading to suppression of endogenous steroid production and Cushing's syndrome. |
| Databáze: | MEDLINE |
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