Effect of botulinum toxin type-A in patients with focal spasticity.

Autor:	Selimoglu E; Erenkoy Physical Medicine and Rehabilitation Hospital, Istanbul, Turkey., Turgut ST; Department of Physical Medicine and Rehabilitation, Karaman Government Hospital, Karaman, Turkey., Akpinar P; Department of Physical Medicine and Rehabilitation, Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkey., Yumusakhuylu Y; Department of Physical Medicine and Rehabilitation, Istanbul Medeniyet University, Goztepe Training and Research Hospital, Istanbul, Turkey., Haliloglu S; Department of Physical Medicine and Rehabilitation, Istanbul Occupational Disease Hospital, Istanbul, Turkey., Baklacioglu HS; Department of Physical Medicine and Rehabilitation, Bakirkoy Prof. Dr. Mazhar Osman Psychology and Neurology Hospital, Istanbul, Turkey., Icagasioglu A; Department of Physical Medicine and Rehabilitation, Istanbul Medeniyet University, Goztepe Training and Research Hospital, Istanbul, Turkey.
Jazyk:	angličtina
Zdroj:	Northern clinics of Istanbul [North Clin Istanb] 2015 Jan 24; Vol. 1 (3), pp. 153-157. Date of Electronic Publication: 2015 Jan 24 (Print Publication: 2014).
DOI:	10.14744/nci.2014.43531
Abstrakt:	Objective: To investigate the effect of botulinum toxin type-A (BTX-A) on spasticity and function in patients with focal spasticity. Methods: Patients attended to the outpatient clinic of physical medicine and rehabilitation department with a diagnosis of focal spasticity and had BTX-A injections because of spasticty were evaluated for the study. Demographic data, exercise status, orthoses, drugs used for spasticity, functional status, stages of spasticity of muscles before and after 1 st and 3 rd months of BTX-A injection according to Modified Ashworth Scale (MAS) were evaluated retrospectively. MedCalc 11.6 statistical program was used for statistical analyses. Statistical significance was defined as p<0.05. Results: Forty-nine patients with focal spasticity were recruited for the study (35 men, 14 women). Mean age of the patients was 21.59±20.09 years. The patients had cerebral palsy (CP, n=28), 19 had hemiplegia (n=19) and paraplegia (n=2). Forty-three patients were using orthoses and exercising regularly. Mean Pediatric Functional Independence Measurement (WeeFIM) scores of the patients with CP was 54.82±28.91 and according to the Gross Motor Function Classification System (GMFCS) the patients were in stages 2 (14%), 3 (46%), 4 (11%) and 5 (29%). Mean Functional Independence Measure (FIM) of hemiplegic and paraplegic patients was 80.80±20.88. Brunnstrom staging scores for upper extremity (3.52±0.96), hands (2.68±0.82), lower extremity (4.57±1.01) were calculated. MAS muscles demonstrated statistically significant decrease in spasticity at the end of first and third months (p<0.05). Conclusion: We saw a significant decrease in the spasticity of upper and lower extremities in patients with focal spasiticity who received BTX-A injections. We suggest that if BTX-A injections are supported with orthoses and exercise programs, then functional status of the patients would be better. Competing Interests: No conflict of interest was declared by the authors.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu