Genetic conflicts: the usual suspects and beyond.

Autor:	McLaughlin RN Jr; Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA., Malik HS; Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA hsmalik@fhcrc.org.; Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Jazyk:	angličtina
Zdroj:	The Journal of experimental biology [J Exp Biol] 2017 Jan 01; Vol. 220 (Pt 1), pp. 6-17.
DOI:	10.1242/jeb.148148
Abstrakt:	Selfishness is pervasive and manifests at all scales of biology, from societies, to individuals, to genetic elements within a genome. The relentless struggle to seek evolutionary advantages drives perpetual cycles of adaptation and counter-adaptation, commonly referred to as Red Queen interactions. In this review, we explore insights gleaned from molecular and genetic studies of such genetic conflicts, both extrinsic (between genomes) and intrinsic (within genomes or cells). We argue that many different characteristics of selfish genetic elements can be distilled into two types of advantages: an over-replication advantage (e.g. mobile genetic elements in genomes) and a transmission distortion advantage (e.g. meiotic drivers in populations). These two general categories may help classify disparate types of selfish genetic elements. Competing Interests: The authors declare no competing or financial interests. (© 2017. Published by The Company of Biologists Ltd.)
Databáze:	MEDLINE
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