Toll-like receptor (TLR)7 expression in mycosis fungoides and psoriasis: a case-control study.

Autor: El Tawdy AM; Dermatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt., Amin IM; Dermatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt., Abdel Hay RM; Dermatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt., Hassan AS; Dermatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt., Gad ZS; Surgical Oncology Department, National Cancer Institute, Cairo University, Cairo, Egypt., Rashed LA; Clinical Biochemistry Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Jazyk: angličtina
Zdroj: Clinical and experimental dermatology [Clin Exp Dermatol] 2017 Mar; Vol. 42 (2), pp. 172-177. Date of Electronic Publication: 2017 Jan 05.
DOI: 10.1111/ced.13008
Abstrakt: Background: Toll-like receptors (TLRs) have been implicated in various dermatological diseases. TLR agonists have the capacity to potently activate the innate immune cells of patients with advanced, refractory, cutaneous T-cell lymphoma (CTCL).
Aim: To detect TLR7 gene expression in mycosis fungoides (MF) (a neoplastic skin condition) and to compare it with psoriasis (an inflammatory skin condition) in an attempt to clarify the pathogenic role played by TLR7 in both conditions.
Methods: This case-control study enrolled 28 patients with MF: 30 patients with psoriasis, and 30 age- and sex-matched healthy controls (HCs). A 4-mm punch skin biopsy was obtained from lesional skin of patients and from normal skin of HCs for detection of TLR7 gene expression using real-time PCR.
Results: Mean TLR7 level in patients with MF (0.4 ± 0.23) was significantly lower than in patients with psoriasis (1.49 ± 0.46) and in HCs (1.22 ± 0.44) (P < 0.001), and mean TLR7 level in patients with psoriasis was significantly higher than in HCs (P < 0.03). Based on MF staging, 21.4% of patients had stage Ia, 28.6% had stage Ib, 28.6% had stage IIa and 21.4% had stage IIb disease. Comparing the TLR7 levels in relation to MF staging revealed the lowest mean value was in stage IIb and highest mean value in stage Ia, and this was significant (P < 0.001).
Conclusion: Disturbed innate immunity might play a role in the pathogenesis of neoplastic and inflammatory skin conditions. TLR7 could be useful as a prognostic factor in MF.
(© 2017 British Association of Dermatologists.)
Databáze: MEDLINE
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