Effect of inversion time on the precision of myocardial late gadolinium enhancement quantification evaluated with synthetic inversion recovery MR imaging.

Autor: Varga-Szemes A; Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Ashley River Tower, 25 Courtenay Drive, Charleston, SC, 29425-2260, USA., van der Geest RJ; Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands., Schoepf UJ; Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Ashley River Tower, 25 Courtenay Drive, Charleston, SC, 29425-2260, USA. schoepf@musc.edu., Spottiswoode BS; Siemens Medical Solutions, Chicago, IL, USA., De Cecco CN; Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Ashley River Tower, 25 Courtenay Drive, Charleston, SC, 29425-2260, USA., Muscogiuri G; Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Ashley River Tower, 25 Courtenay Drive, Charleston, SC, 29425-2260, USA.; Department of Imaging, Bambino Gesu Children's Hospital IRCCS, Rome, Italy., Wichmann JL; Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Ashley River Tower, 25 Courtenay Drive, Charleston, SC, 29425-2260, USA.; Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Frankfurt, Germany., Mangold S; Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Ashley River Tower, 25 Courtenay Drive, Charleston, SC, 29425-2260, USA.; Department of Diagnostic and Interventional Radiology, Eberhard-Karls University Tuebingen, Tuebingen, Germany., Fuller SR; Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Ashley River Tower, 25 Courtenay Drive, Charleston, SC, 29425-2260, USA., Maurovich-Horvat P; MTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, Budapest, Hungary., Merkely B; MTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, Budapest, Hungary., Litwin SE; Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, SC, USA., Vliegenthart R; Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Ashley River Tower, 25 Courtenay Drive, Charleston, SC, 29425-2260, USA.; Center for Medical Imaging-North East Netherlands, Department of Radiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Suranyi P; Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Ashley River Tower, 25 Courtenay Drive, Charleston, SC, 29425-2260, USA.
Jazyk: angličtina
Zdroj: European radiology [Eur Radiol] 2017 Aug; Vol. 27 (8), pp. 3235-3243. Date of Electronic Publication: 2017 Jan 03.
DOI: 10.1007/s00330-016-4665-z
Abstrakt: Objectives: To evaluate the influence of inversion time (TI) on the precision of myocardial late gadolinium enhancement (LGE) quantification using synthetic inversion recovery (IR) imaging in patients with myocardial infarction (MI).
Methods: Fifty-three patients with suspected prior MI underwent 1.5-T cardiac MRI with conventional magnitude (MagIR) and phase-sensitive IR (PSIR) LGE imaging and T1 mapping at 15 min post-contrast. T1-based synthetic MagIR and PSIR images were calculated with a TI ranging from -100 to +150 ms at 5-ms intervals relative to the optimal TI (TI 0 ). LGE was quantified using a five standard deviation (5SD) and full width at half-maximum (FWHM) thresholds. Measurements were compared using one-way analysis of variance.
Results: The MagIR sy technique provided precise assessment of LGE area at TIs ≥ TI 0 , while precision was decreased below TI 0 . The LGE area showed significant differences at ≤ -25 ms compared to TI 0 using 5SD (P < 0.001) and at ≤ -65 ms using the FWHM approach (P < 0.001). LGE measurements did not show significant difference over the analysed TI range in the PSIR sy images using either of the quantification methods.
Conclusions: T1 map-based PSIR sy images provide precise quantification of MI independent of TI at the investigated time point post-contrast. MagIR sy -based MI quantification is precise at TI 0 and at longer TIs while showing decreased precision at TI values below TI 0 .
Key Points: • Synthetic IR imaging retrospectively generates LGE images at any theoretical TI • Synthetic IR imaging can simulate the effect of TI on LGE quantification • Fifteen minutes post-contrast MagIR sy accurately quantifies infarcts from TI 0 to TI 0   + 150 ms • Fifteen minutes post-contrast PSIR sy provides precise infarct size independent of TI • Synthetic IR imaging has further advantages in reducing operator dependence.
Databáze: MEDLINE
Externí odkaz: