[The effect of palonosetron on rocuronium-induced withdrawal movement].

Autor:	Park KB; Keimyoung University, School of Medicine, Department of Anesthesiology and Pain Medicine, Daegu, República da Coreia., Jeon Y; Kyungpook National University, School of Dentistry, Department of Anesthesiology, Daegu, República da Coreia., Yi J; Kyungpook National University, School of Medicine, Department of Anesthesiology and Pain Medicine, Daegu, República da Coreia., Kim JH; Kyungpook National University, School of Medicine, Department of Anesthesiology and Pain Medicine, Daegu, República da Coreia., Chung SY; Kyungpook National University, School of Medicine, Department of Anesthesiology and Pain Medicine, Daegu, República da Coreia., Kwak KH; Kyungpook National University, School of Medicine, Department of Anesthesiology and Pain Medicine, Daegu, República da Coreia. Electronic address: kwakkh@knu.ac.kr.
Jazyk:	portugalština
Zdroj:	Revista brasileira de anestesiologia [Rev Bras Anestesiol] 2017 Jul - Aug; Vol. 67 (4), pp. 337-341. Date of Electronic Publication: 2016 Dec 29.
DOI:	10.1016/j.bjan.2016.04.010
Abstrakt:	Background: Rocuronium causes pain and withdrawal movement during induction of anesthesia. In this study, palonosetron was investigated to have analgesic effect on the reduction of rocuronium-induced withdrawal movement. Methods: 120 patients were randomly assigned to one of three groups to receive either saline, lidocaine 20mg, or palonosetron 0.075mg with a tourniquet applied two minutes before thiopental sodium (5mg.kg -1 ) was given intravenously. After loss of consciousness, rocuronium (0.6mg.kg -1 ) was injected and the withdrawal movement was estimated by 4-point scale in a double-blind manner. Results: The overall incidence of rocuronium withdrawal movement was 50% with lidocaine (p=0.038), 38% with palonosetron (p=0.006) compared with 75% for saline. The incidence of no pain to mild pain was significantly lower in the lidocaine and palonosetron groups (85% and 92% respectively) than in the saline group (58%). However, there was no significant difference in withdrawal movement between the lidocaine and palonosetron groups. There was no severe movement with palonosetron. Conclusion: Pretreatment of palonosetron with venous occlusion may attenuate rocuronium-induced withdrawal movement as effective as the use of lidocaine. It suggested that peripheral action of palonosetron was effective to reduce rocuronium-induced withdrawal movement. (Copyright © 2016. Publicado por Elsevier Editora Ltda.)
Databáze:	MEDLINE
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