Merosesquiterpene Congeners from the Australian Sponge Hyrtios digitatus as Potential Drug Leads for Atherosclerosis Disease.
| Autor: | Wahab HA; Eskitis Institute for Drug Discovery, Griffith University, Brisbane 4111, Australia. nuruhuda.abdulwahab@griffithuni.edu.au.; School of Fundamental Science, Universiti Malaysia Terengganu, Kuala Terengganu 21030, Malaysia. nuruhuda.abdulwahab@griffithuni.edu.au., Pham NB; Eskitis Institute for Drug Discovery, Griffith University, Brisbane 4111, Australia. nhuda@umt.edu.my., Muhammad TS; School of Fundamental Science, Universiti Malaysia Terengganu, Kuala Terengganu 21030, Malaysia. sifzizul@umt.edu.my.; Institute of Marine Biotechnology, Universiti Malaysia Terengganu, Kuala Terengganu 21030, Malaysia. sifzizul@umt.edu.my., Hooper JN; Eskitis Institute for Drug Discovery, Griffith University, Brisbane 4111, Australia. n.pham@griffith.edu.au.; Queensland Museum, Brisbane 4101, Australia. n.pham@griffith.edu.au., Quinn RJ; Eskitis Institute for Drug Discovery, Griffith University, Brisbane 4111, Australia. r.quinn@griffith.edu.au. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Marine drugs [Mar Drugs] 2016 Dec 27; Vol. 15 (1). Date of Electronic Publication: 2016 Dec 27. |
| DOI: | 10.3390/md15010006 |
| Abstrakt: | A study of the chemical constituents from the Australian Sponge Hyrtios digitatus has provided a perspective on the connection between the chemistry and biology of the puupehenones, a unique and unusual class of merosesquiterpenes. In this study, a new tetracyclic merosesquiterpene, 19-methoxy-9,15-ene-puupehenol ( 1 ) was isolated from the marine sponge Hyrtios digitatus along with the known 20-methoxy-9,15-ene-puupehenol ( 2 ). Their structures were elucidated on the basis of spectroscopic data (¹H and 13 C NMR) in combination with experimental electronic circular dichroism (ECD) data. Compounds 1 and 2 are active at 1.78 μM and 3.05 μM, respectively, on Scavenger Receptor-Class B Type 1 HepG2 (SR-B1 HepG2) stable cell lines, targeting atherosclerosis disease. Competing Interests: The authors declare no conflict of interest. |
| Databáze: | MEDLINE |
| Externí odkaz: |
|