Cardiovascular Risk Factors in Cluster Headache.
| Autor: | Lasaosa SS; Departments of Neurology., Diago EB; Departments of Neurology., Calzada JN; Internal Medicine, Clinical University Hospital 'Lozano Blesa,' Zaragoza, Spain., Benito AV; Departments of Neurology. |
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| Jazyk: | angličtina |
| Zdroj: | Pain medicine (Malden, Mass.) [Pain Med] 2017 Jun 01; Vol. 18 (6), pp. 1161-1167. |
| DOI: | 10.1093/pm/pnw305 |
| Abstrakt: | Background: Patients with cluster headache tend to have a dysregulation of systemic blood pressure such as increased blood pressure variability and decreased nocturnal dipping. This pattern of nocturnal nondipping is associated with end-organ damage and increased risk of cardiovascular disease. Objective: To determine if cluster headache is associated with a higher risk of cardiovascular disease. Methods: Cross-sectional study of 33 cluster headache patients without evidence of cardiovascular disease and 30 age- and gender-matched healthy controls. Ambulatory blood pressure monitoring was performed in all subjects. We evaluate anthropometric, hematologic, and structural parameters (carotid intima-media thickness and ankle-brachial index). Results: Of the 33 cluster headache patients, 16 (48.5%) were nondippers, a higher percentage than expected. Most of the cluster headache patients (69.7%) also presented a pathological ankle-brachial index. In terms of the carotid intima-media thickness values, 58.3% of the patients were in the 75th percentile, 25% were in the 90th percentile, and 20% were in the 95th percentile. In the control group, only five of the 30 subjects (16.7%) had a nondipper pattern ( P = 0.004), with 4.54% in the 90th and 95th percentiles ( P = 0.012 and 0.015). Conclusions: Compared with healthy controls, patients with cluster headache presented a high incidence (48.5%) of nondipper pattern, pathological ankle-brachial index (69.7%), and intima-media thickness values above the 75th percentile. These findings support the hypothesis that patients with cluster headache present increased risk of cardiovascular disease. (© 2016 American Academy of Pain Medicine. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com) |
| Databáze: | MEDLINE |
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