Spongian-16-one Diterpenes and Their Anatomical Distribution in the Australian Nudibranch Goniobranchus collingwoodi.

Autor: Forster LC; School of Chemistry and Molecular Biosciences, ‡School of Biological Sciences, and §Institute for Molecular Bioscience, The University of Queensland , Brisbane, QLD 4072, Australia., Winters AE; School of Chemistry and Molecular Biosciences, ‡School of Biological Sciences, and §Institute for Molecular Bioscience, The University of Queensland , Brisbane, QLD 4072, Australia., Cheney KL; School of Chemistry and Molecular Biosciences, ‡School of Biological Sciences, and §Institute for Molecular Bioscience, The University of Queensland , Brisbane, QLD 4072, Australia., Dewapriya P; School of Chemistry and Molecular Biosciences, ‡School of Biological Sciences, and §Institute for Molecular Bioscience, The University of Queensland , Brisbane, QLD 4072, Australia., Capon RJ; School of Chemistry and Molecular Biosciences, ‡School of Biological Sciences, and §Institute for Molecular Bioscience, The University of Queensland , Brisbane, QLD 4072, Australia., Garson MJ; School of Chemistry and Molecular Biosciences, ‡School of Biological Sciences, and §Institute for Molecular Bioscience, The University of Queensland , Brisbane, QLD 4072, Australia.
Jazyk: angličtina
Zdroj: Journal of natural products [J Nat Prod] 2017 Mar 24; Vol. 80 (3), pp. 670-675. Date of Electronic Publication: 2016 Dec 29.
DOI: 10.1021/acs.jnatprod.6b00936
Abstrakt: Six new (1-6) spongian-16-one analogues have been characterized from the Australian nudibranch species Goniobranchus collingwoodi, along with four known spongian-16-one derivatives. The structures and relative configuration were suggested by spectroscopic analyses informed by molecular modeling. Dissection of animal tissue revealed that the mantle and viscera differ in their terpene composition. Whole body extracts were not toxic to brine shrimp (Artemia sp.), but were unpalatable to palaemon shrimp (Palaemon serenus) at a concentration found within the nudibranch. Individual terpenes were not cytotoxic to human lung (NCIH-460), colorectal (SW620), and liver (HepG2) cancer cells.
Databáze: MEDLINE