Action and Function of Vitamin D in Digestive Tract Physiology and Pathology.
| Autor: | Peppelenbosch MP; Department of Gasteroenterology and Hepatology, Erasmus MC - University Medical Center Rotterdam's Gravendijkwal 230, NL-3015 CE Rotterdam. Netherlands., Fuhler GM; Department of Gasteroenterology and Hepatology, Erasmus MC - University Medical Center Rotterdam's Gravendijkwal 230, NL-3015 CE Rotterdam. Netherlands., Verhaar AP; Department of Gasteroenterology and Hepatology, Erasmus MC - University Medical Center Rotterdam's Gravendijkwal 230, NL-3015 CE Rotterdam. Netherlands., van der Laan LJW; Department of Surgery, Erasmus MC - University Medical Center Rotterdam's Gravendijkwal 230, NL-3015 CE Rotterdam. Netherlands. |
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| Jazyk: | angličtina |
| Zdroj: | Current medicinal chemistry [Curr Med Chem] 2017; Vol. 24 (9), pp. 928-936. |
| DOI: | 10.2174/0929867323666161228145137 |
| Abstrakt: | Background: The body of biomedical literature on Vitamin D effector mechanisms in gastrointestinal biology and pathophysiology is rapidly expanding. Accordingly, new possibilities of vitamin D biology-based therapeutical intervention in gastroenterological disease are being identified. However, the literature lacks a concise review on these developments, hampering comprehension of the possibilities involved for many in the community. Results: Genetic vitamin D receptor (VDR) polymorphisms and other VDR biology regulation are involved in predisposition to gastrointestinal cancers and might allow tailored strategies for managing those individuals especially at risk, e.g. through vitamin D supplementation. Likewise, modulation of Hedgehog signaling by vitamin D analogues may have promise in combating gastrointestinal cancers or improving barrier function in IBD, but shortage in vitamin D levels may also influence inflammatory conditions of the gut through direct interaction with the mucosal immune system. Evidence justifying population-wide monitoring for vitamin D status is accumulating. Conclusion: There is kaleidoscopic interaction of vitamin D biology with many aspects of gastrointestinal tract biology. Vitamin D appears an attractive target for personalized approaches like precision and P4 medicine. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.) |
| Databáze: | MEDLINE |
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