Further intracellular proteins and signaling pathways regulated by angiotensin-(1-7) in human endothelial cells.

Autor: Meinert C; Institute of Experimental and Clinical Pharmacology and Toxicology, Medical Faculty Mannheim, Universität Heidelberg, Mannheim, Germany; Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland., Kohse F; Departments of Obstetrics and Pediatric Surgery, Division of Women and Child Health, Universität Leipzig, Leipzig, Germany., Böhme I; Departments of Obstetrics and Pediatric Surgery, Division of Women and Child Health, Universität Leipzig, Leipzig, Germany., Gembardt F; Division of Nephrology, Department of Internal Medicine III, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany., Tetzner A; Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland; Departments of Obstetrics and Pediatric Surgery, Division of Women and Child Health, Universität Leipzig, Leipzig, Germany., Wieland T; Institute of Experimental and Clinical Pharmacology and Toxicology, Medical Faculty Mannheim, Universität Heidelberg, Mannheim, Germany., Greenberg B; Division of Cardiology, University of California, San Diego, USA., Walther T; Institute of Experimental and Clinical Pharmacology and Toxicology, Medical Faculty Mannheim, Universität Heidelberg, Mannheim, Germany; Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland; Departments of Obstetrics and Pediatric Surgery, Division of Women and Child Health, Universität Leipzig, Leipzig, Germany.
Jazyk: angličtina
Zdroj: Data in brief [Data Brief] 2016 Dec 08; Vol. 10, pp. 354-363. Date of Electronic Publication: 2016 Dec 08 (Print Publication: 2017).
DOI: 10.1016/j.dib.2016.12.004
Abstrakt: In 2016, Meinert et al. (doi: 10.1016/j.jprot.2015.09.020) published the first 25 proteins in a protein array regulated in Human Umbilical Vein Endothelial Cells (HUVEC) by the heptapeptide angiotensin (Ang)-(1-7) and the first 10 intracellular signaling cascades at different time points. This supporting data article shows further proteins and pathways stimulated by Ang-(1-7) in human endothelial cells at time points of 1 h, 3 h, 6 h, and 9 h. HUVECs were stimulated with Ang-(1-7), and regulated proteins were identified via antibody microarray. Bioinformatics software IPA was used for association of regulated proteins to metabolic pathways.
Databáze: MEDLINE
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