Vitamin D on Early Stages of Diabetic Kidney Disease: A Cross-sectional Study in Patients with Type 1 Diabetes Mellitus.

Autor: Felício JS; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará , Belém, Pará , Brazil., Luz RM; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará , Belém, Pará , Brazil., de Melo FT; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará , Belém, Pará , Brazil., de Souza Resende F; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará , Belém, Pará , Brazil., de Oliveira AF; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará , Belém, Pará , Brazil., Peixoto AS; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará , Belém, Pará , Brazil., Abrahão Neto JF; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará , Belém, Pará , Brazil., Carvalho CT; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará , Belém, Pará , Brazil., da Silva DD; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará , Belém, Pará , Brazil., Dos Santos MC; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará , Belém, Pará , Brazil., de Queiroz NN; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará , Belém, Pará , Brazil., de Lemos MN; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará , Belém, Pará , Brazil., Yamada ES; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará , Belém, Pará , Brazil., Felício KM; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará , Belém, Pará , Brazil.
Jazyk: angličtina
Zdroj: Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2016 Dec 12; Vol. 7, pp. 149. Date of Electronic Publication: 2016 Dec 12 (Print Publication: 2016).
DOI: 10.3389/fendo.2016.00149
Abstrakt: Context: Genetic and environmental factors are involved in the pathogenesis of type 1 diabetes mellitus (T1DM), and vitamin D (VD) deficiency appears as a candidate to risk factor for developing diabetic kidney disease (DKD).
Objective: The purpose of study was to evaluate the existence of an association between low levels of VD and the presence and degree of DKD in T1DM.
Patients and Methods: We performed a cross-sectional study, between November 2014 and December 2015. Levels of 25(OH)D and albuminuria were analyzed in 37 patients with T1DM and normal glomerular filtration rate. Thirty-six subjects were evaluated as a control group.
Results: Patients with T1DM and hypovitaminosis D had higher levels of albuminuria compared to those with normal VD levels [albuminuria (log 10 ) = 1.92 vs. 1.44; p  < 0.05]. When we have separated the group of patients according to stage of DKD in patients with normo, micro, and macroalbuminuria, there are lower levels of 25(OH)D in the last when compared to the first two groups (26.7 ± 6.2, 24.8 ± 7.0, and 15.9 ± 7.6 ng/ml; p  < 0.05, respectively). In T1DM group, we have found correlations between VD levels and both albuminuria and DKD stages ( r  = -0.5; p  < 0.01 and r  = -0.4; p  < 0.05, respectively). A simple linear regression model, with albuminuria as the dependent variable and VD as an independent variable, showed r 2 = 0.2 and p  < 0.01.
Conclusion: Our data suggest an association between reduced levels of VD and the presence and severity of DKD.
Databáze: MEDLINE
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