25-Hydroxyvitamin D concentrations, asthma and eczema in childhood: The generation R study.

Autor: Tromp IIM; From the Generation R Study Group, The Netherlands; Departments of Pediatrics, Erasmus University, Rotterdam, The Netherlands., Franco OH; Departments of Epidemiology, Erasmus University, Rotterdam, The Netherlands., van den Hooven EH; Departments of Epidemiology, Erasmus University, Rotterdam, The Netherlands., Heijboer AC; Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands., Jaddoe VWV; From the Generation R Study Group, The Netherlands; Departments of Epidemiology, Erasmus University, Rotterdam, The Netherlands; Departments of Pediatrics, Erasmus University, Rotterdam, The Netherlands., Duijts L; Departments of Epidemiology, Erasmus University, Rotterdam, The Netherlands; Division of Respiratory Medicine, Erasmus University, Rotterdam, The Netherlands; Division of Neonatology, Erasmus University, Rotterdam, The Netherlands., de Jongste JC; Division of Respiratory Medicine, Erasmus University, Rotterdam, The Netherlands., Moll HA; Departments of Pediatrics, Erasmus University, Rotterdam, The Netherlands., Kiefte-de Jong JC; Departments of Epidemiology, Erasmus University, Rotterdam, The Netherlands; Global Public Health, Leiden University College, The Hague, The Netherlands; Departments of Pediatrics, Erasmus University, Rotterdam, The Netherlands. Electronic address: j.c.kiefte-dejong@erasmusmc.nl.
Jazyk: angličtina
Zdroj: Clinical nutrition (Edinburgh, Scotland) [Clin Nutr] 2018 Feb; Vol. 37 (1), pp. 169-176. Date of Electronic Publication: 2016 Dec 08.
DOI: 10.1016/j.clnu.2016.11.019
Abstrakt: Background & Aims: A role of vitamin D in the development of respiratory and allergic disease in children remains unclear. It may be likely that vitamin D has an effect on airway inflammation, but only few studies examined the effect in children. We aimed to examine whether serum 25-hydroxyvitamin D (25(OH) vitamin D) concentrations are associated with the fraction of exhaled nitric oxide (FeNO), airway interrupter resistance (Rint), physician diagnosed asthma ever, wheezing and eczema in a population-based cohort study in 6 year old children.
Methods: Serum 25(OH) vitamin D concentration was assessed in 3815 children. 25(OH) vitamin D concentrations ≥75 nmol/L were considered as sufficient, between 50 and 75 nmol/L as insufficient, and <50 nmol/L as deficient. FeNO and Rint were measured at the research center. Data on physician diagnosed asthma, wheezing, and eczema were obtained by parent-reported questionnaires.
Results: In comparison with sufficient 25(OH) vitamin D concentration, deficient concentrations were associated with elevated FeNO of ≥25 ppb (OR: 2.54; 95% CI: 1.34-4.80). In addition, deficient and insufficient 25(OH) vitamin D concentrations were associated with a lower Rint (Z-score: -1.26; 95% CI: -1.66 to -0.85) (ß: -0.75; 95% CI: -1.08 to -0.42), and increased risks of eczema (OR: 1.65; 95% CI: 1.13-2.41) (OR: 1.44; 95% CI: 1.06-1.95). Insufficient 25(OH) vitamin D concentration were associated with a decreased risk of physician diagnosed asthma ever (OR: 0.59; 95% CI: 0.38-0.94).
Conclusions: Our results indicate that lower 25(OH) vitamin D levels are associated with elevated FeNO levels, but lower Rint values. Lower 25(OH) vitamin D levels are also associated with a decreased risk for asthma diagnoses but an increased risk for eczema.
(Copyright © 2016 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.)
Databáze: MEDLINE
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