Delayed and decreased LV untwist and unstrain rate in mutation carriers for hypertrophic cardiomyopathy.

Autor:	Kauer F; Department of Cardiology, The Thoraxcenter, Erasmus University Medical Center, Rotterdam, The Netherlands., van Dalen BM; Department of Cardiology, The Thoraxcenter, Erasmus University Medical Center, Rotterdam, The Netherlands., Michels M; Department of Cardiology, The Thoraxcenter, Erasmus University Medical Center, Rotterdam, The Netherlands., Schinkel AF; Department of Cardiology, The Thoraxcenter, Erasmus University Medical Center, Rotterdam, The Netherlands., Vletter WB; Department of Cardiology, The Thoraxcenter, Erasmus University Medical Center, Rotterdam, The Netherlands., van Slegtenhorst M; Department of Genetics, The Thoraxcenter, Erasmus University Medical Center, Rotterdam, The Netherlands., Soliman OI; Department of Cardiology, The Thoraxcenter, Erasmus University Medical Center, Rotterdam, The Netherlands., Geleijnse ML; Department of Cardiology, The Thoraxcenter, Erasmus University Medical Center, Rotterdam, The Netherlands.
Jazyk:	angličtina
Zdroj:	European heart journal. Cardiovascular Imaging [Eur Heart J Cardiovasc Imaging] 2017 Apr 01; Vol. 18 (4), pp. 383-389.
DOI:	10.1093/ehjci/jew213
Abstrakt:	Background: The echocardiographic focus to detect abnormalities in genetically hypertrophic cardiomyopathy (HCM) affected subjects without left ventricular (LV) hypertrophy (G+/LVH-) has been on diastolic abnormalities in transmitral flow and longitudinal myocardial function with tissue Doppler imaging. The aim of this study was to assess diastolic LV unstrain and untwist. Methods and Results: Forty-one consecutive genotyped family members of HCM patients (mean age 37 ± 11 years, 16 men) and 41 age- and gender-matched healthy volunteers underwent speckle-tracking echocardiography to measure untwist and unstrain. No significant differences between G+/LVH- and control subjects were seen in maximal systolic twist and global longitudinal strain. In diastole, the early peak untwist rate was significantly lower in G+/LVH- subjects compared with control subjects (62 ± 19°s - 1 vs. 76 ± 30°s - 1, P <0.05), whereas the late peak untwist rate tended to be higher. Untwist from maximal twist until the first 20% of diastole was delayed in G+/LVH- subjects (39.3 ± 12.9% vs. 51.3 ± 15.6%, P <0.005). Late diastolic unstrain rate was significantly higher in G+/LVH- subjects in the inferoseptal wall (111 ± 33 s - 1 vs. 94 ± 32 s - 1, P = 0.024), the inferolateral wall (105 ± 42 vs. 75 ± 35 s - 1, P = 0.007) and the anteroseptal wall (97 ± 26 vs. 80 ± 23 s - 1, P = 0.010). Unstrain from maximal twist until the first 20% of diastole was delayed in G+/LVH- subjects in the inferoseptal (18.9 ± 14.0% vs. 30.1 ± 17.7%, P = 0.005), inferolateral (27.1 ± 16.3% vs. 39.2 ± 18.0%, P = 0.015) and anteroseptal (19.1 ± 14.7% vs. 35.8 ± 18.5%, P = 0.0003) segments. Conclusions: In mutation carriers, for HCM LV, untwist and unstrain are delayed and untwist rate and unstrain rate are decreased. (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2016. For permissions, please email: journals.permissions@oup.com.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu