Immunohistochemical Expression of CD 56 and ALDH 1 in Common Salivary Gland Tumors.

Autor: Seifi S; Department of Oral and Maxillofacial Pathology, School of Dentistry, Babol University of Medical Sciences, Babol, Iran., Seyedmajidi M; Department of Oral and Maxillofacial Pathology, School of Dentistry, Babol University of Medical Sciences, Babol, Iran., Salehinejad J; Dental Research Centre, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran., Gholinia H; Health Research Institute, Babol University of Medical Science, Mazandaran, Iran., Aliakbarpour F; Department of Oral and Maxillofacial Pathology, School of Dentistry, Babol University of Medical Sciences, Babol, Iran.
Jazyk: angličtina
Zdroj: Iranian journal of otorhinolaryngology [Iran J Otorhinolaryngol] 2016 Nov; Vol. 28 (89), pp. 389-397.
Abstrakt: Introduction: Natural killer (NK) cells, of which CD 56 is a specific marker, play an important role in host defense against tumors. Cancer stem cells, of which aldehyde dehydrogenase isoform 1 (ALDH 1 ) is an immunohistochemical marker, are a group of tumorigenic cells which are involved in migration and tumor recurrences. We aimed to evaluate the expression of ALDH 1 and CD 56 in common salivary gland tumors, as well as their relationship with each other and with a number of clinicopathologic factors.
Materials and Methods: Forty-five paraffin blocks of salivary gland tumors (pleomorphic adenoma, mucoepidermoid carcinoma and adenoid cystic carcinoma, 15 samples each) were selected. Malignant tumors were classified into two groups: low-grade (including mucoepidermoid carcinoma grade I) and high-grade (including mucoepidermoid carcinoma grade III and adenoid cystic carcinoma). Immunohistochemical staining for ALDH 1 and CD 56 markers was performed. Data were analyzed using SPSS (20) and the Chi-square test.
Results: CD 56 expression was significantly higher in benign and high-grade malignant tumors (P=0.01). ALDH 1 overexpressed in all three salivary tumors, but not to statistically significant degree (P=0.54). There was no statistically significant correlation between ALDH 1 and CD 56 expression with demographic factors (age, gender, or location of tumor; P>0.05).
Conclusion: It appears that the number of NK cells and their function change in different types of salivary gland tumors (benign/malignant) and stroma. NK cells are important components of the anti-tumor system; therefore immune dysfunction is associated with tumor progression in tumors of the salivary gland. ALDH 1 overexpression suggests its role in tumorogenesis, but ALDH 1 is not involved in the morphogenesis of salivary gland tumors.
Databáze: MEDLINE
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