Emerging biopharmaceuticals from bioactive peptides derived from marine organisms.

Autor: Anjum K; Ocean College, Zhejiang University, Hangzhou, China., Abbas SQ; Faculty of Pharmacy, Gomal University, D.I. Khan, Khyber-Pakhtunkhwa, Pakistan., Akhter N; Ocean College, Zhejiang University, Hangzhou, China., Shagufta BI; Department of Zoology, Kohat University of Science and Technology (KUST), D.I. Khan, Khyber-Pakhtunkhwa, Pakistan., Shah SAA; Ocean College, Zhejiang University, Hangzhou, China., Hassan SSU; Ocean College, Zhejiang University, Hangzhou, China.
Jazyk: angličtina
Zdroj: Chemical biology & drug design [Chem Biol Drug Des] 2017 Jul; Vol. 90 (1), pp. 12-30. Date of Electronic Publication: 2017 Feb 06.
DOI: 10.1111/cbdd.12925
Abstrakt: Biologically active natural products are spontaneous medicinal entrants, which encourage synthetic access for enhancing and supporting drug discovery and development. Marine bioactive peptides are considered as a rich source of natural products that may provide long-term health, in addition to many prophylactic and curative medicinal drug treatments. The large literature concerning marine peptides has been collected, which shows high potential of nutraceutical and therapeutic efficacy encompassing wide spectra of bioactivities against a number of infection-causing agents. Their antimicrobial, antimalarial, antitumor, antiviral, and cardioprotective actions have achieved the attention of the pharmaceutical industry toward new design of drug formulations, for treatment and prevention of several infections. However, the mechanism of action of many peptide molecules has been still untapped. So in this regard, this paper reviews several peptide compounds by which they interfere with human pathogenesis. This knowledge is one of the key tools to be understood especially for the biotransformation of biomolecules into targeted medicines. The fact that different diseases have the capability to fight at different sites inside the body can lead to a new wave of increasing the chances to produce targeted medicines.
(© 2016 John Wiley & Sons A/S.)
Databáze: MEDLINE
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