| Autor: |
Geneugelijk K; Laboratory for Translational Immunology, University Medical Center Utrecht , Utrecht , Netherlands., Hönger G; Laboratory for Transplantation Immunology and Nephrology, Department of Biomedicine, University Hospital Basel , Basel , Switzerland., van Deutekom HW; Department of Theoretical Biology and Bioinformatics, University Utrecht , Utrecht , Netherlands., Hösli IM; Department for Obstetrics and Fetomaternal Medicine, University Hospital Basel , Basel , Switzerland., Schaub S; Clinic for Transplantation Immunology and Nephrology, University Hospital Basel , Basel , Switzerland., Spierings E; Laboratory for Translational Immunology, University Medical Center Utrecht , Utrecht , Netherlands. |
| Abstrakt: |
Inherited paternal HLA antigens from the semi-allogeneic fetus may trigger maternal immune responses during pregnancy, leading to the production of child-specific HLA antibodies. The prevalence of these HLA antibodies increases with the number of successful pregnancies. In the present study, we investigated the effect of a single prior miscarriage on HLA antibody formation during a subsequent successful pregnancy. Women with a successful pregnancy with one or more prior miscarriages ( n = 229) and women with a successful pregnancy without a prior miscarriage ( n = 58), and their children were HLA typed. HLA antibody analyses were performed in these women to identify whether HLA antibodies were formed against mismatched HLA class-I antigens of the last child. The percentage of immunogenic antigens was significantly lower after a single successful pregnancy that was preceded by a single miscarriage ( n = 18 women) compared to a successful pregnancy that was preceded by a first successful pregnancy ( n = 62 women). Thus, our data suggest that a previous miscarriage has a different impact on child-specific HLA antibody formation during a subsequent successful pregnancy than a previous successful pregnancy. The lower immunogenicity in these women cannot be explained by reduced numbers of immunogenic B-cell and T-cell epitopes. In conclusion, our observations indicate that increasing gravidity is not related to an increased prevalence of HLA antibodies in a single successful pregnancy that was preceded by a single prior miscarriage. |
