Interpersonal violence in posttraumatic women: brain networks triggered by trauma-related pictures.
| Autor: | Neumeister P, Feldker K, Heitmann CY, Helmich R, Gathmann B, Becker MPI, Straube T |
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| Jazyk: | angličtina |
| Zdroj: | Social cognitive and affective neuroscience [Soc Cogn Affect Neurosci] 2017 Apr 01; Vol. 12 (4), pp. 555-568. |
| DOI: | 10.1093/scan/nsw165 |
| Abstrakt: | Interpersonal violence (IPV) is one of the most frequent causes for the development of posttraumatic stress disorder (PTSD) in women. Trauma-related triggers have been proposed to evoke automatic emotional responses in PTSD. The present functional magnetic resonance study investigated the neural basis of trauma-related picture processing in women with IPV-PTSD (n = 18) relative to healthy controls (n = 18) using a newly standardized trauma-related picture set and a non-emotional vigilance task. We aimed to identify brain activation and connectivity evoked by trauma-related pictures, and associations with PTSD symptom severity. We found hyperactivation during trauma-related vs neutral picture processing in both subcortical [basolateral amygdala (BLA), thalamus, brainstem] and cortical [anterior cingulate cortex (ACC), medial prefrontal cortex (mPFC), insula, occipital cortex] regions in IPV-PTSD. In patients, brain activation in amygdala, ACC, insula, occipital cortex and brainstem correlated positively with symptom severity. Furthermore, connectivity analyses revealed hyperconnectivity between BLA and dorsal ACC/mPFC. Results show symptom severity-dependent brain activation and hyperconnectivity in response to trauma-related pictures in brain regions related to fear and visual processing in women suffering from IPV-PTSD. These brain mechanisms appear to be associated with immediate responses to trauma-related triggers presented in a non-emotional context in this PTSD subgroup. (© The Author (2016). Published by Oxford University Press.) |
| Databáze: | MEDLINE |
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