Secondhand Smoke Exposure and Subclinical Cardiovascular Disease: The Multi-Ethnic Study of Atherosclerosis.

Autor: Jones MR; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD mjone132@jhu.edu., Magid HS; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD., Al-Rifai M; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.; Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins University, Baltimore, MD., McEvoy JW; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.; Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins University, Baltimore, MD., Kaufman JD; Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA., Hinckley Stukovsky KD; Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA., Szklo M; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD., Polak J; Department of Radiology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA., Burke GL; Division of Public Health Sciences, Wake Forest School of Medicine, Winston- Salem, NC., Post WS; Division of Cardiology, Johns Hopkins University, Baltimore, MD., Blaha MJ; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.; Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins University, Baltimore, MD., Navas-Acien A; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.; Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
Jazyk: angličtina
Zdroj: Journal of the American Heart Association [J Am Heart Assoc] 2016 Dec 19; Vol. 5 (12). Date of Electronic Publication: 2016 Dec 19.
DOI: 10.1161/JAHA.115.002965
Abstrakt: Background: Few studies have evaluated the association between secondhand smoke (SHS) and subclinical cardiovascular disease among ethnically diverse populations. This study assesses the impact of SHS on inflammation and atherosclerosis (carotid intima-media thickness, coronary artery calcification, and peripheral arterial disease).
Methods and Results: We examined 5032 nonsmoking adults aged 45 to 84 years without prior cardiovascular disease participating in the Multi-Ethnic Study of Atherosclerosis (MESA) from 2000 to 2002. SHS exposure was determined by self-report, and urinary cotinine was measured in a representative subset (n=2893). The multi-adjusted geometric mean ratios (95% CIs) for high-sensitivity C-reactive protein and interleukin-6 comparing 407 participants with SHS ≥12 h/wk versus 3035 unexposed participants were 1.13 (1.02-1.26) and 1.04 (0.98-1.11), respectively. The multi-adjusted geometric mean ratio for carotid intima-media thickness was 1.02 (0.97-1.07). Fibrinogen and coronary artery calcification were not associated with SHS. The prevalence of peripheral arterial disease (ankle-brachial index ≤0.9 or ≥1.4) was associated with detectable urinary cotinine (odds ratio, 2.10; 95% CI, 1.09-4.04) but not with self-reported SHS. Urinary cotinine was not associated with inflammation or carotid intima-media thickness.
Conclusions: Despite limited exposure assessment, this study supports the association of SHS exposure with inflammation and peripheral arterial disease.
(© 2016 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.)
Databáze: MEDLINE
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