Cryptococcemia in an HIV-negative patient with decompensated liver cirrhosis.

Autor:	Kandula M; Division of Internal Medicine, University of Illinois College of Medicine at Peoria, Peoria, IL, USA; manasakandula14@gmail.com., Kelkar AH; Division of Internal Medicine, University of Illinois College of Medicine at Peoria, Peoria, IL, USA., Liberio N; Division of Internal Medicine, University of Illinois College of Medicine at Peoria, Peoria, IL, USA., Aiyer MK; Division of Internal Medicine, University of Illinois College of Medicine at Peoria, Peoria, IL, USA.
Jazyk:	angličtina
Zdroj:	Journal of community hospital internal medicine perspectives [J Community Hosp Intern Med Perspect] 2016 Dec 15; Vol. 6 (6), pp. 33383. Date of Electronic Publication: 2016 Dec 15 (Print Publication: 2016).
DOI:	10.3402/jchimp.v6.33383
Abstrakt:	Background: Cryptococcal infections have been mostly associated with immunocompromised individuals, 80-90% of whom have been HIV-positive patients. Increasingly, cryptococcal infections are being reported in cirrhotic patients who are HIV-negative. The underlying immunologic defects in cirrhotic patients seem to play an important role in predisposing them to cryptococcosis and affecting their morbidity and mortality. Case Presentation: We present a case of disseminated cryptococcosis in an HIV-negative patient with underlying cirrhosis, who had rapid worsening of his hyponatremia with renal failure and was unable to recover, despite aggressive measures. Conclusion: Cryptococcus is a more common culprit of infections seen in cirrhotic patients than what it was previously known, and a high index of suspicion is required to diagnose these patients. Identification of poor prognostic factors, early diagnosis and intervention is crucial in the management of these patients. Competing Interests: and funding The authors have not received any funding or benefits from industry or elsewhere to conduct this study.
Databáze:	MEDLINE
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