Comparative Study between Perfusion Changes and Positive Findings on Coronary Flow Reserve.

Autor:	Costantini CR; Hospital Cardiológico Costantini, Curitiba, PR, Brazil., Ramires JA; Instituto do Coração, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil., Costantini CO; Hospital Cardiológico Costantini, Curitiba, PR, Brazil., Denk MA; Hospital Cardiológico Costantini, Curitiba, PR, Brazil., Tarbine SG; Hospital Cardiológico Costantini, Curitiba, PR, Brazil., Santos MF; Hospital Cardiológico Costantini, Curitiba, PR, Brazil., Zanuttini DA; Hospital Cardiológico Costantini, Curitiba, PR, Brazil., Silveira CW; Hospital Cardiológico Costantini, Curitiba, PR, Brazil., Souza AM; Hospital Cardiológico Costantini, Curitiba, PR, Brazil., Macedo RM; Hospital Cardiológico Costantini, Curitiba, PR, Brazil.
Jazyk:	Portuguese; English
Zdroj:	Arquivos brasileiros de cardiologia [Arq Bras Cardiol] 2017 Jan; Vol. 108 (1), pp. 38-46. Date of Electronic Publication: 2016 Dec 08.
DOI:	10.5935/abc.20160184
Abstrakt:	Background: Functional assessment of coronary artery obstruction is used in cardiology practice to correlate anatomic obstructions with flow decrease. Among such assessments, the study of the coronary fractional flow reserve (FFR) has become the most widely used. Objective: To evaluate the correlation between FFR and findings of ischemia obtained by noninvasive methods including stress echocardiography and nuclear medicine and the presence of critical coronary artery obstruction. Methods: Retrospective study of cases treated with systematized and standardized procedures for coronary disease between March 2011 and August 2014. We included 96 patients with 107 critical coronary obstructions (> 50% in the coronary trunk and/or ≥ 70% in other segments) estimated by quantitative coronary angiography (QCA) and intracoronary ultrasound (ICUS). All cases presented ischemia in one of the noninvasive studies. Results: All 96 patients presented ischemia (100%) in one of the functional tests. On FFR study with adenosine 140 g/kg/min, 52% of the cases had values ≤ 0.80. On correlation analysis for FFR ≤ 0.80, the evaluation of sensitivity, specificity, positive and negative predictive values, accuracy, and ROC curve in relation to the stenosis degree and length, and presence of ischemia, no significant values or strong correlation were observed. Conclusion: Coronary FFR using a cut-off value of 0.80 showed no correlation with noninvasive ischemia tests in patients with severe coronary artery obstructions on QCA and ICUS. Competing Interests: Potential Conflict of Interest No potential conflict of interest relevant to this article was reported.
Databáze:	MEDLINE
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